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T4382 Sigma-Aldrich

apo-Transferrin human

powder, ≥98% (agarose gel electrophoresis)

Synonym: Human transferrin, Siderophilin

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Properties

Related Categories Apo-Transferrin, Biochemicals and Reagents, Plasma & Blood Proteins, Plasma, Blood, and Related Proteins and Reagents, Proteins and Derivatives More...
Quality Level   200
biological source   human
assay   ≥98% (agarose gel electrophoresis)
form   powder
mol wt   76-81 kDa
Iron content   ≤0.005%
application(s)   cell culture | mammalian: suitable
impurities   HIV and HBsAg, source material tested negative
solubility   H2O: 50 mg/mL
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... TF(7018)

Description

General description

Apo-transferrin human is a glycoprotein, possessing homologous carboxyl and amino domain. Both the domain binds to one molecule of iron. Only 30% of transferrin is saturated with iron in the amino domain. Apo-transferrin in human is encoded by the gene TF which is localized on human chromosome 3q22.1.

Application

Apo-Transferrin human has been used:
• to determine the competitive binding of bismuth to albumin and transferrin by fast performance liquid chromatography (FPLC)
• to study titanium-transferrin complex by electrochemical method
• in the preparation of transferrin solution and in the formation of conjugates with ruthenium-complexes for cellular viability studies

Packaging

1 g in glass bottle

100, 500 mg in glass bottle

Biochem/physiol Actions

Apo-transferrin is an iron transport protein. The concentration of transferrin in blood plasma is about 35 μM. Transferrin also functions in the transport of therapeutic, diagnostic and toxic ions like Ga3+, Ru3+ and Al3+. Polymorphism in TF gene has pathological implications in Parkinson′s disease.

Apo-transferrin is required for the survival and differentiation of oligodendroglial cells.

Other Notes

Non-heme iron-transport protein.

Linkage

Similar to T 2252

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What is the carbohydrate content of human transferrin?
We have found the information on transferrin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.According to the table, Transferrin is 6 percent carbohydrate, citing G.A. Jamieson, J. Biol. Chem. 240(7), 2914-2920 (1965).The table also gives information on the percentage of each type of monosaccharide that is present.
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Protocols & Articles

Articles

Plasma Derived Proteins and Enzymes

Despite their complexity, blood and plasma are abundant biological resources for the discovery of drug targets and biomarkers for human disease. It is estimated that plasma may contain as many as 40,...
BioFiles 2006, 1.5, 2.
Keywords: Applications, Gas chromatography, Type

Related Content

Transferrin in Cell Culture

Importance and uses of transferrins in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures
Keywords: Cell culture, Culture media, Gene expression, Glycosylations, Oxidations

Peer-Reviewed Papers
15

References

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