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T4567 Sigma-Aldrich

Transforming Growth Factor-β Soluble Receptor III human

>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: TGF-β sRIII

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Properties

Related Categories Cancer Research, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines & Growth Factors,
biological source   human
recombinant   expressed in NSO cells
assay   >97% (SDS-PAGE)
form   lyophilized powder
mol wt   mol wt 100 kDa by SDS-PAGE (glycosylation)
  predicted mol wt 84 kDa
packaging   pkg of 1 mg
storage condition   avoid repeated freeze/thaw cycles
impurities   endotoxin, tested
UniProt accession no.   Q03167
storage temp.   −20°C
Gene Information   human ... TGFBR3(7049)

Description

Analysis Note

The receptor-mediated activity is measured by its ability to inhibit the TGF-β2 bioactivity in HT-2 cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5 mg bovine serum albumin

Application

Transforming Growth Factor-β soluble receptor III human can be used to study TGF-β- mediated signal tranduction.

Biochem/physiol Actions

Transforming Growth Factor-β soluble receptor III human also known as betaglycan facilitates as an inhibin co-receptor with ActRII and mediates functional antagonism of activin signalling.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Request a Serum Sample

Cell Culture Guide
Protocols & Articles

Articles

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units. The disaccharide units that are the basis of all glycosaminoglycans (except keratan) are a combination...
Vicki Caligur
BioFiles 2008, 3.10, 4.
Keywords: Adhesion, Aminations, Angiogenesis, Anticoagulants, Apoptosis, Atomic absorption spectroscopy, Cancer, Cell biology, Cell proliferation, Cell signaling, Cellular processes, Central Nervous System, Chromatography, Coagulation, Degradations, Enzyme-linked immunosorbent assay, Epimerizations, Gene expression, Genetic, Genomics, Growth factors, Help, High performance liquid chromatography, Inflammation, Ion-exchange chromatography, Ligands, Mass spectrometry, Methods, Microarray Analysis, Morphogenesis, Nuclear magnetic resonance spectroscopy, Phosphorylations, Polymerase chain reaction, Polymerization reactions, Proteomics, Reductive aminations, Sequences, Spectroscopy, Sulfations, Transcription, Type, transformation

Glycosaminoglycans and Proteoglycans

Glycosaminoglycans (GAGs) are large linear polysaccharides constructed of repeating disaccharide units with the primary configurations containing an amino sugar (either GlcNAc or GalNAc) and an uroni...
Glycobiology Analysis Manual, 2nd Edition
Keywords: Adhesion, Catalysis, Coagulation, Degradations, Growth factors, Inflammation, Ligands, Pentose phosphate pathway, Polymerization reactions, Sulfations

Related Content

Cell Culture Troubleshooting Guide

Cell culture has become one of the most fundamental techniques for modeling biological systems, and is of increasing importance in the biotechnology and pharmaceutical sectors as well as an essential...
Keywords: Antibiotics, Apoptosis, Cell attachment, Cell culture, Cryopreservation, Filtration, Growth factors, Pharmaceutical, Phase transitions

Peer-Reviewed Papers
15

References

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