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T4952 Sigma-Aldrich

Tanshinone IIA

≥97% (HPLC)

Synonym: 1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione, Dan Shen ketone

  • CAS Number 568-72-9

  • Empirical Formula (Hill Notation) C19H18O3

  • Molecular Weight 294.34

  •  MDL number MFCD00238692

  •  PubChem Substance ID 329826804

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Properties

Related Categories Anti-Proliferative Agents, Antioxidant, Antitumor Agents, Cancer Research, Cell Biology,
Quality Level   100
assay   ≥97% (HPLC)
form   powder
color   orange to dark red
solubility   methanol: 5 mg/mL, clear, red-orange to red
storage temp.   2-8°C
SMILES string   Cc1coc2-c3ccc4c(CCCC4(C)C)c3C(=O)C(=O)c12
InChI   1S/C19H18O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,9H,4-5,8H2,1-3H3
InChI key   HYXITZLLTYIPOF-UHFFFAOYSA-N

Description

Application

Tanshinone IIA (Dan Shen ketone), vasoactive cardioprotective drug, is used in a wide variety of studies to asses is potential therapeutic value and mechanisms of action which include inhibiting LDL oxidation, monocyte adhesion to endothelium, smooth muscle cell migration and proliferation, macrophage cholesterol accumulation, proinflammatory cytokine expression and platelet aggregation.

Packaging

25 mg in poly bottle

5 mg in glass insert

Biochem/physiol Actions

Phenanthrenequinone constituent of Chinese medicinal herb Danshen (Salvia miltiorrhiza). Anti-inflammatory. Antioxidant. Cytotoxic against a variety of cell lines, inlcuding human glioma cells.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Traditional Medicinals and Cancer

Traditional Chinese Medicine (TCM) is a healing art that has been practiced for thousands of years. The practice of TCM is a holistic approach that includes the use of herbal preparations, acupunctur...
Lynn Stephenson, Product Specialist, and Chloe McClanahan, Product Manager
Biofiles Vol. 8, No. 6
Keywords: Analgesics, Antitumor agents, Apoptosis, Cancer, Drug discovery, Fractionation, High performance liquid chromatography, Metabolites, Metabolomics, Nuclear magnetic resonance spectroscopy, Pharmaceutical

Peer-Reviewed Papers
15

References

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