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T5050 Sigma-Aldrich

Transforming Growth Factor-β1 from porcine platelets

TGF-β1, powder, suitable for cell culture

Synonym: TGF-β1

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Description

Analysis Note

The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.

Biochem/physiol Actions

Transforming growth factor-β1 (TGF-β1) is produced by many cell types, but is reported to be most concentrated in mammalian platelets, where it is present at approximately four times the level of TGF-β2.

Transforming growth factor-β1 (TGF-β) is a multifunctional polypeptide growth factor. TGF-β mediates cell proliferation, differentiation and migration. Important cellular functions such as inflammation, extracellular matrix synthesis, epithelial restoration and developmental processes are also controlled by TGF-β. TGF-β controls the regulation of enamel mineralization in porcine. TGF-β is associated with the development of idiopathic pulmonary fibrosis (a chronic lung disease). TGF-β promotes epithelial-mesenchymal transition (EMT) and contributes to proliferation and metastasis of cancer. The TGF-β induced EMT is observed in kidney fibrosis. TGF-β is stimulates regeneration of intestinal tissue.

Physical form

Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 0.05 mg bovine serum albumin per μg cytokine.

Application

Transforming Growth Factor-β1 from porcine platelets has been used in chondrogenic differentiation. It has also been used in immobilization process.

General description

The TGFB (transforming growth factor-β) gene is mapped to pig (Sus scrofa) chromosome between 6q11-q21. In mammals, TGFβ is present in three isoforms (TGFβ1, TGFβ2 and TGFβ3), of which TGFβ1 is predominant.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


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Cell Culture Guide
Protocols & Articles

Articles

Cellular Derived Blood Proteins and Enzymes

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Transforming Growth Factor (TGF) Superfamily

The transforming growth factor-β (TGF-β) superfamily of cytokines include the structurally related subfamily of TGF-βs, the subfamily of bone morphogenic proteins (BMP), decapentaplegic (dpp) and Vg1...
Jennifer Fries
BioFiles 2009, 4.5, 21.
Keywords: Cancer, Gene expression, Growth factors, Ligands, Phosphorylations, Transduction, Type

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Peer-Reviewed Papers
15

References

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