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T5639 Sigma-Aldrich

Ticarcillin disodium salt

Synonym: (2S,5R,6R)-6-[[(2R)-Carboxy-3-thienylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt

  • CAS Number 4697-14-7

  • Empirical Formula (Hill Notation) C15H14N2Na2O6S2

  • Molecular Weight 428.39

  •  MDL number MFCD07787410

  •  PubChem Substance ID 24900306

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application,
biological source   semisynthetic
InChI Key   ZBBCUBMBMZNEME-QBGWIPKPSA-L
form   powder or crystals
color   white to light yellow
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

Description

Other Notes

β-Lactam antibiotic

Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.

Packaging

1G

Application

Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. It is commonly used in combination with clavulanate in order to improve it′s efficacy. It is used to study appropriate dosing in pediatric patients who have cystic fibrosis.

Biochem/physiol Actions

Ticarcillin is a β-Lactam antibiotic that prevents bacterial cell wall biosynthesis at the level of peptidogylcan cross-linking by inhibiting peptidoglycan transpeptidases. It is derived from penicillin and is similar to carbenicillin in action. Ticarcillin is susceptible to degradation by ß-lactamases.

General description

Chemical structure: ß-lactam

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
XM9410000
Protocols & Articles
Peer-Reviewed Papers
15

References

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