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T5955 Sigma-Aldrich

3,4,5,6-Tetrahydroxyxanthone hydrate

≥98% (HPLC)

Synonym: 3,4,5,6-Tetrahydroxy-9H-xanthen-9-one hydrate, MB7

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels,
Quality Level   100
assay   ≥98% (HPLC)
color   light brown to brown
solubility   DMSO: >10 mg/mL
storage temp.   2-8°C
SMILES string   O.Oc1ccc2C(=O)c3ccc(O)c(O)c3Oc2c1O
InChI   1S/C13H8O6.H2O/c14-7-3-1-5-9(16)6-2-4-8(15)11(18)13(6)19-12(5)10(7)17;/h1-4,14-15,17-18H;1H2
InChI key   ZFTTXYRPFMYDRT-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

3,4,5,6-Tetrahydroxyxanthone is a Na/K-ATPase inihibitor that inhibits pump function without activating the kinase signaling function. It inhibits Na/K ATPase pump action with an affinity comparable to ouabain, but does not alter Na or ATP affinity, is not blocked by potassium, and it does not activate the Src complex or downstream kinases.

Preparation Note

3,4,5,6-Tetrahydroxyxanthone hydrate is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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