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T6271 Sigma-Aldrich

Tylosin tartrate

powder, BioReagent, suitable for cell culture

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Mechanism of Action,
product line   BioReagent
form   powder
potency   ≥800 units/mg tylosin
application(s)   cell culture | mammalian: suitable
color   off-white to yellow
solubility   H2O: ≤50 mg/mL
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-positive bacteria
  mycoplasma
storage temp.   2-8°C
SMILES string   O[C@H]([C@@H](O)C(O)=O)C(O)=O.CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@@H](C)C(=O)\C=C\C(C)=C\[C@@H]1CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC
InChI   1S/C46H77NO17.C4H6O6/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35;5-1(3(7)8)2(6)4(9)10/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3;1-2,5-6H,(H,7,8)(H,9,10)/b15-14+,23-18+;/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-;1-,2-/m11/s1
InChI key   ICVKYYINQHWDLM-KBEWXLTPSA-N

Description

General description

Chemical structure: macrolide

Packaging

1, 5, 10 g in poly bottle

Application

Tylosin is a mcrolide antibiotic commonly used in veterinary medicine. It has been used to study protein synthesis at the 50S ribosome, implant site abscess prevention in cattle, disposition kinetics and Mycoplasma gallisepticumand Mycoplasma meleagridis infections. It is recommended for use in cell culture applications at 8 mg/L.

Biochem/physiol Actions

Mode of Action: Tylosin Tartrate inhibits bacterial protein synthesis by binding to the 50S (L27 protein) ribosome.

Antimicrobial Spectrum: This product acts against gram-positive bacteria and mycoplasma.

Components

This product is a mixture of tylosin A, B, C, and D tartrates.

Caution

Stock solutions should be filter sterilized and stored at 2-8°C. These solutions are stable at 37°C for 3 days.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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