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T6700 Sigma-Aldrich

TRAM-34

≥98% (HPLC), solid

Synonym: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole

  • CAS Number 289905-88-0

  • Empirical Formula (Hill Notation) C22H17ClN2

  • Molecular Weight 344.84

  •  MDL number MFCD09842562

  •  PubChem Substance ID 329826852

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
color   off-white
solubility   DMSO: 2 mg/mL
  H2O: insoluble
storage temp.   2-8°C
SMILES string   Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4
InChI   1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H
InChI key   KBFUQFVFYYBHBT-UHFFFAOYSA-N

Description

Application

TRAM-34 has been used to study its effect on the prevention of vascular restenosis after balloon angioplasty.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

TRAM-34 exhibits 100-fold selectivity (Kd = 20 nM) for IKCa1 channels over other K+ channels (Charybdotoxin, Kd = 5 nM, Clotrimazole, Kd = 70 nM; Nitrendipine Kd = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,.

TRAM-34 is a potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

TRAM-34 is soluble in DMSO at 2 mg/ml. However, it is insoluble in water.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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