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T6764 Sigma-Aldrich

Triprolidine hydrochloride

≥99%

Synonym: (E)-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride, trans-2-[3-(1-Pyrrolidinyl)-1-p-tolylpropenyl]pyridine hydrochloride

  • CAS Number 6138-79-0

  • Empirical Formula (Hill Notation) C19H22N2 · HCl

  • Molecular Weight 314.85

  •  MDL number MFCD00039044

  •  PubChem Substance ID 24277808

  •  NACRES NA.77

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Properties

Related Categories Antagonists- Histaminergics, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
Quality Level   200
assay   ≥99%
solubility   alcohol: soluble 1 in 1.5 of solvent
  chloroform: soluble 1 in less than 1 of solvent
  H2O: soluble 50 mg/mL, clear, colorless to yellow
originator   GlaxoSmithKline
storage temp.   2-8°C
SMILES string   CC(C=C1)=CC=C1/C(C2=NC=CC=C2)=C\CN3CCCC3.Cl
InChI   1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;/h2-3,6-12H,4-5,13-15H2,1H3;1H/b18-11+;
InChI key   WYUYEJNGHIOFOC-NWBUNABESA-N
Gene Information   human ... HRH1(3269)

Description

Application

Triprolidine has been used as a H1 histaminergic inhibitor to study its effect on long-term potentiation (LTP) in tuberomammillary nucleus (TMN) neurons.

Packaging

1, 5 g in poly bottle

Biochem/physiol Actions

H1 histamine receptor antagonist.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Triprolidine hydrochloride is soluble in water at 50 mg/ml and yields a clear, colorless to yellow solution. It is also soluble in alcohol (1 in 1.5 of solvent) and chloroform (1 in less than 1 of solvent).

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
UT7658000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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