T7040 Sigma

Tyrphostin 1


Synonym: (4-Methoxybenzylidene)malononitrile



Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98%
potency   >1250 μM IC50 (negative control)
mp   113-116 °C(lit.)
solubility   chloroform: soluble 50 mg/mL, clear, light yellow
  DMSO: soluble
storage temp.   2-8°C
Gene Information   human ... EGFR(1956)


Biochem/physiol Actions

EGFR tyrosine kinase inhibitor.

Tyrphostin 1 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain. Tyrphostin 1 is also known to block EGF-dependent receptor autophosphorylation,. Furthermore, studies have reported that tyrphostin 1 can block Ca2+ channels and inhibit growth in vascular smooth muscle cells,.


25 mg in poly bottle

Preparation Note

Tyrphostin 1 dissolves in chloroform at 50 mg/ml to yield a clear, light yellow solution. It is also soluble in DMSO.


Tyrphostin 1 has been used to study its effect on the increase of transgene expression in HeLa and NIH3T3 cells.

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Safety Information

NONH for all modes of transport
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