T7402 Sigma


from Taxus brevifolia, ≥95% (HPLC), powder



Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,
biological source   Taxus brevifolia
assay   ≥95% (HPLC)
form   powder
color   white
mp   213 °C (dec.)(lit.)
solubility   DMSO: 50 mg/mL (can be stored frozen for several months)
  methanol: soluble 50 mg/mL, clear, colorless (undergoes transesterification)
  H2O: soluble (hydrolyzes)
  ethanol: soluble
Mode of action   DNA synthesis | interferes
antibiotic activity spectrum   viruses
originator   Bristol-Myers Squibb
storage temp.   2-8°C
Gene Information   human ... BCL2(596)



Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions.


1, 5, 25 mg in glass insert

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

Paclitaxel is soluble in methanol at 50 mg/ml and yields a clear, colorless solution. It is also soluble in DMSO (50 mg/ml), water and ethanol.


Paclitaxel has been used as a component of the dechorionation buffer for Gryllus bimaculatus eggs. Paclitaxel has also been used for studying its effect on the movement of all-trans retinoic acid (ATRA) differentiated NB4 cells.

Biochem/physiol Actions

Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Chemical structure: taxoide

Price and Availability

LC-MS Grade Solvents and Reagents

Fatty Acid Extraction Kit

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Safety & Documentation

Safety Information

GHS08  GHS08
Signal word 
Hazard statements 
Precautionary statements 
NONH for all modes of transport
WGK Germany 
Protocols & Articles


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Peer-Reviewed Papers


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