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T7508 Sigma

Tetracaine hydrochloride


Synonym: 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester, Amethocaine hydrochloride



Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels,
assay   ≥99%
solubility   chloroform: soluble 30 parts
  alcohol: soluble 40 parts
  H2O: soluble mg/mL
  acetone: insoluble
  benzene: insoluble
  diethyl ether: insoluble



Topical ophthalmic anesthetic; used for spinal anesthesia

Tetracaine hydrochloride has been used for studying the pharmacological effects of spinal anesthesia. Tetracaine hydrochloride has also been used as a component of protease digestion buffers.

Biochem/physiol Actions

Blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum.


5, 25, 100 g in poly bottle

Preparation Note

Tetracaine hydrochloride dissolves in water at 50 mg/ml to yield a clear, colorless solution. It is also soluble in 40 parts alcohol and 30 parts chloroform. However, it is practically insoluble in ether benzene or acetone.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Cyclic Nucleotide-Gated (CNG) and Hyperpolarization Activated Cyclic Nucleotide-Gated (HCN) Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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