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T7697 Sigma-Aldrich

I-OMe-Tyrphostin AG 538

solid

Synonym: α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3′,4′-dihydroxyphenyl)ketone, I-OMe-AG 538

  • Empirical Formula (Hill Notation) C17H12INO5

  • Molecular Weight 437.19

  •  MDL number MFCD03453582

  •  PubChem Substance ID 24278758

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Insulin-Like Growth Factor Receptor (IGF1R and IGf2R),
Quality Level   100
form   solid
solubility   DMSO: 50 mg/mL
storage temp.   −20°C
SMILES string   COc1cc(cc(I)c1O)\C=C(/C#N)C(=O)c2ccc(O)c(O)c2
InChI   1S/C17H12INO5/c1-24-15-6-9(5-12(18)17(15)23)4-11(8-19)16(22)10-2-3-13(20)14(21)7-10/h2-7,20-21,23H,1H3/b11-4+
InChI key   HSRMHXWCTRFVHK-NYYWCZLTSA-N
Gene Information   human ... IGF1(3479), IGF1R(3480)

Description

Application

I-OMe-Tyrphostin AG 538 has been used as a cell signaling inhibitor in PC-1 cell lines. It has also been used in high throughput screening assays for IGF1R inhibitors.

Packaging

5 mg in glass bottle

Biochem/physiol Actions

Insulin growth factor 1 (IGF-1) receptor protein tyrosine kinase inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

I-OMe-Tyrphostin AG 538 is soluble in DMSO at 50 mg/ml.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Phosphorylation is a ubiquitous cellular regulatory mechanism that mediates signal transduction pathways, which carry signals from the cell surface to the nucleus or cytoplasm, by altering the activi...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Diseases, Inflammation, Metabolism, Neurodegenerative Diseases, Phosphorylations, Transduction

Peer-Reviewed Papers
15

References

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