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T7924 Sigma

Transforming Growth Factor-α human

TGF-α, recombinant, expressed in E. coli, powder, suitable for cell culture

Synonym: TGF-α, hTGF-α



Amino Acid Sequence

Val-Val-Ser-His-Phe-Asn-Asp-Cys-Pro-Asp-Ser-His-Thr-Gln-Phe-Cys-Phe-His-Gly-Thr-Cys-Arg-Phe-Leu-Val-Gln-Glu-Asp-Lys-Pro-Ala-Cys-Val-Cys-His-Ser-Gly-Tyr-Val-Gly-Ala-Arg-Cys-Glu-His-Ala-Asp-Leu-Leu-Ala [Disulfide bridges: 8-21; 16-32; 34-43]

Analysis Note

The biological activity is measured by its ability to stimulate 3H-thymidine incorpation into BALB/c 3T3 cells.

Biochem/physiol Actions

Transforming growth factor-α (TGF-α), is a 5.5 kDa polypeptide containing 50 amino acids in its mature form. It was originally identified as an agent that reversibly confers a transformed phenotype upon normal non-neoplastic cells, such as normal rat kidney fibroblasts. This activity requires the presence of transforming growth factor-β (TGF-β), which potentiates the action of TGF-α via a separate receptor. TGF-α is synthesized by monocytes, keratinocytes and many tissues and tumors. Mice genetically engineered to be lacking TGF-α expression showed no abnormalities except for the detection of a "wavy" hair coat. TGF-α exerts its action through the EGF receptor.

Physical form

Lyophilized from a 0.2 μm filtered buffered solution.

Price and Availability

Request a Serum Sample

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Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles


Transforming Growth Factor (TGF) Superfamily

The transforming growth factor-β (TGF-β) superfamily of cytokines include the structurally related subfamily of TGF-βs, the subfamily of bone morphogenic proteins (BMP), decapentaplegic (dpp) and Vg1...
Jennifer Fries
BioFiles 2009, 4.5, 21.
Keywords: Cancer, Gene expression, Growth factors, Ligands, Phosphorylations, Transduction, Type

Peer-Reviewed Papers


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