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T8657 Sigma-Aldrich

Trichloroacetic acid

for electrophoresis, suitable for fixing solution (for IEF and PAGE gels), ≥99%

Synonym: TCA

  • CAS Number 76-03-9

  • Linear Formula Cl3CCOOH

  • Molecular Weight 163.39

  •  Beilstein/REAXYS Number 970119

  •  EC Number 200-927-2

  •  MDL number MFCD00004177

  •  PubChem Substance ID 24900550

  •  NACRES NB.22

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Properties

Related Categories Acids, Acids & Bases, Acids and Bases, Biochemicals and Reagents, Buffers,
grade   for electrophoresis
vapor density   <1 (vs air)
vapor pressure   1 mmHg ( 51 °C)
assay   ≥99%
turbidity   ≤3 NTU (1 g/ml)
refractive index   n20/D 1.62 (lit.)
bp   196 °C (lit.)
mp   54-58 °C (lit.)
solubility   H2O: 1 g/mL
density   1.62 g/mL at 25 °C (lit.)
anion traces   chloride (Cl-): ≤0.001%
  nitrate (NO3-): ≤0.002%
  phosphate (PO43-): ≤5 ppm
  sulfate (SO42-): ≤0.02%
cation traces   Fe: ≤0.0005%
  heavy metals (as Pb): ≤0.002%
suitability   suitable for fixing solution (for IEF and PAGE gels)
storage temp.   2-8°C
SMILES string   OC(=O)C(Cl)(Cl)Cl
InChI   1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)
InChI key   YNJBWRMUSHSURL-UHFFFAOYSA-N

Description

General description

Trichloroacetic acid (TCA) is produced during the chlorination of water comprising natural organic material. It is a novel reagent used in clinical laboratories for deproteinization of body fluids. In addition, TCA is also used in the treatment of genital warts and acne scars.

Application

Trichloroacetic acid has been used:
• for hydrolysis of DNA isolated from the cell
• for precipitation of glutathione isolated from seminal plasma
• as a fixative in microscopy

Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.

Packaging

1 kg in glass bottle

250, 500 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
RIDADR 
UN 1839 8 / PGII
WGK Germany 
WGK 2
RTECS 
AJ7875000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Single- & multi-channel pipettes from BRAND
Protocols & Articles

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Peer-Reviewed Papers
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References

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