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T9025 Sigma-Aldrich

Thioridazine hydrochloride

≥99%

Synonym: 10-[2-(1-Methyl-2-piperidyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride

  • CAS Number 130-61-0

  • Empirical Formula (Hill Notation) C21H26N2S2 · HCl

  • Molecular Weight 407.04

  •  EC Number 204-992-8

  •  MDL number MFCD00012655

  •  PubChem Substance ID 57654711

  •  NACRES NA.77

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Properties

Related Categories Antagonists - Dopaminergics, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Calcium Channel Modulators,
InChI Key   NZFNXWQNBYZDAQ-UHFFFAOYSA-N
Quality Level   100
assay   ≥99%
solubility   H2O: soluble 250 mg plus 5 ml of solvent, clear, colorless to faintly yellow
  chloroform: soluble
  diethyl ether: insoluble
  ethanol: soluble
  methanol: soluble
Gene Information   human ... DRD2(1813)

Description

Application

Thioridazine hydrochloride has been used as an intercalating agent for analyzing the integrity of double-stranded DNA (dsDNA) using square-wave voltammetry (SWV) techniques. Thioridazine hydrochloride has also been used as a positive control for the inhibition of hepatic enzyme cytochrome P4502D6 (CYP2D6) in human liver microsomes.

Biochem/physiol Actions

D2 dopamine receptor antagonist; phenothazine antipsychotic with reduced extrapyramidal side effects; Ca2+ channel blocker.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Preparation Note

250 mg of thioridazine hydrochloride is soluble in 5 ml of water and yields a clear, colorless to faint yellow solution. Thioridazine hydrochloride is also soluble in methanol, ethanol, and chloroform, but it is insoluble in ether.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
SP2275000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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