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TRUEPVAS Sigma-Aldrich

TrueGel3D Polymer

Modifed for slow gelling (SLO-PVA)

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Description

Components

TRUEPVAS contains SLO-PVA solution in phosphate buffer, TrueGel3D thioglycerol and water

Application

SLO-PVA polymer is used with crosslinkers (CD/PEG crosslinkers) to establish stable hydrogels

Caution

Avoid frequent freeze-thaw cycles and store SLO-PVA in small portions

Features and Benefits

• Contains synthetic polymer (PVA) functionalized with thiol reactive groups for slow gelation
• Non degradable polymer

General description

PVA polymers are functionalized with thiol-reactive groups, which react at a slower rate with thiol groups of crosslinkers (CD/PEG crosslinkers) to form stable hydrogels. The slow gelation kinetics allows enough time to conveniently manipulate the solution before the onset of homogenous gel formation. The thioglycerol is used to maintain hydrogel strength and also as a control to compare cellular behavior in peptide-modified versus unmodified hydrogels.

Safety & Documentation

Safety Information

RIDADR 
UN 1789 8 / PGIII
Protocols & Articles

Articles

True Gel3D™ Troubleshooting guide

From our library of Articles, Sigma-Aldrich presents True Gel3D™ Troubleshooting guide
Keywords: Adhesion

TrueGel3D™ Hydrogel for 3D Cell Culture

TrueGel3D™ is a biochemically defined hydrogel formed by mixing polymers with crosslinkers. Compared to other hydrogels based on a biological extract from animal cells (e.g. mouse EHS tumor cells), T...
Keywords: Adhesion, Buffers, Cancer, Cell culture, Growth factors, Immobilization, Immunostaining, Ligands, Microscopy, PAGE, SDS PAGE

Protocols

Advanced Protocol: How to Customize your TrueGel3D™ Hydrogel

The identity and concentration of peptides or proteins can be varied when constructing a TrueGel 3D™ hydrogel. This peptide concentration optimization may be important for specific applications such ...
Keywords: Adhesion, High performance liquid chromatography, Ligands, Oxidations

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