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U100 Sigma-Aldrich

Urapidil hydrochloride

solid

Synonym: 6-[[3-[4-(o-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil hydrochloride

  • CAS Number 64887-14-5

  • Empirical Formula (Hill Notation) C20H29N5O3 · HCl

  • Molecular Weight 423.94

  •  MDL number MFCD00078601

  •  PubChem Substance ID 24277811

  •  NACRES NA.77

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Properties

Related Categories Adrenergics, Adrenergics - Antagonists, Antagonists- Adrenergics, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
Quality Level   200
form   solid
color   white
solubility   H2O: soluble 25 mg/mL, clear, colorless to very faintly yellow
SMILES string   Cl[H].COc1ccccc1N2CCN(CCCNC3=CC(=O)N(C)C(=O)N3C)CC2
InChI   1S/C20H29N5O3.ClH/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3;/h4-5,7-8,15,21H,6,9-14H2,1-3H3;1H
InChI key   KTMLZVUAXJERAT-UHFFFAOYSA-N
Gene Information   human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), HTR1A(3350)

Description

General description

The adrenoreceptor α 1a gene (ADRA1A) is mapped to human chromosome 8p21.2. It codes for an α-adrenergic receptor.

Packaging

100, 500 mg in poly bottle

Biochem/physiol Actions

α1-adrenoceptor antagonist; 5-HT1A serotonin receptor partial agonist; anti-hypertensive.
The adrenoreceptor α 1a gene (ADRA1A) participates in smooth muscle contraction. It is also required for vasoconstriction of blood vessels throughout the body such as the skin, gastrointestinal system, genitourinary system, kidney and brain. ADRA1A plays a major role in glycogenolysis and gluconeogenesis of adipose tissue in the liver. It also plays a crucial role in sympathetic nervous system.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Preparation Note

Urapidil hydrochloride is soluble in water at 25 mg/ml to yield a clear, colorless to very faint yellow solution.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
YQ9862000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Antihypertensive Agents

Agents that inhibit angiontensin-converting enzymes (ACE) and angiotensin II formation are essential to cardiovascular medicine.1 These inhibitors are used not only to treat essential hypertension an...
Sami Barghshoon
BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, PAGE, Reductions

New Trifl uoroborate Salts for Suzuki Coupling from Aldrich R&D

Trifluoroborates are air-stable alternatives to boronic acids in palladium-catalyzed Suzuki–Miyaura cross-coupling reactions.1,2 They are more robust, easier to handle, and less prone to protodeboron...
Aldrich ChemFiles 2005, 5.5, 11.
Keywords: Catalysis, Chemfiles, Coupling reactions, Cross couplings

Peer-Reviewed Papers
15

References

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