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U101 Sigma-Aldrich

5-Methylurapidil

solid

Synonym: 5-Methyl-6[[3-[4-(2-methoxyphenyl)-1-piperazinyl]­propyl]­amino]-1,3-dimethyluracil

  • CAS Number 34661-85-3

  • Empirical Formula (Hill Notation) C21H31N5O3

  • Molecular Weight 401.50

  •  MDL number MFCD00078602

  •  PubChem Substance ID 24277800

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Properties

Related Categories Adrenergics, Adrenergics - Antagonists, Antagonists- Adrenergics, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
form   solid
color   white
solubility   H2O: 0.4 mg/mL
  0.1 M HCl: 3.8 mg/mL
SMILES string   Cl[H].COc1ccccc1N2CCN(CCCNC3=C(C)C(=O)N(C)C(=O)N3C)CC2
InChI   1S/C21H31N5O3.ClH/c1-16-19(23(2)21(28)24(3)20(16)27)22-10-7-11-25-12-14-26(15-13-25)17-8-5-6-9-18(17)29-4;/h5-6,8-9,22H,7,10-15H2,1-4H3;1H
InChI key   WAZDYFHTLYHMKO-UHFFFAOYSA-N
Gene Information   human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Description

Application

5-Methylurapidil has been used for competitive binding in radioligand binding assays.

Packaging

10, 50 mg in poly bottle

Biochem/physiol Actions

Selective α1A-adrenoceptor antagonist; antihypertensive.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

5-Methylurapidil is soluble in water at 0.4 mg/ml and is also soluble in 0.1 M HCl at 3.8 mg/ml.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Alpha 1 Adrenoceptor Modulators

α1-Adrenoceptors are widely distributed, and are activated either by norepinephrine released from sympathetic nerve terminals or by epinephrine released from the adrenal medulla. Receptor activation ...
Keywords: Apoptosis, Atomic absorption spectroscopy, Gene expression, Gluconeogenesis, Transduction

Peer-Reviewed Papers
15

References

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