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U104 Sigma-Aldrich

UK 14,304

Synonym: 5-Bromo-N-(2-imidazolin-2-yl)-6-quinoxalinamine, 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine, Brimonidine

  • CAS Number 59803-98-4

  • Empirical Formula (Hill Notation) C11H10BrN5

  • Molecular Weight 292.13

  •  MDL number MFCD00153878

  •  PubChem Substance ID 24277812

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Properties

Related Categories Adrenergics, Adrenergics - Agonists, Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
InChI Key   XYLJNLCSTIOKRM-UHFFFAOYSA-N
solubility   45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL
  DMSO: >6.5 mg/mL
  ethanol: <8 mg/mL (warm)
  H2O: insoluble
Gene Information   human ... ADRA1A(148), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Description

Application

UK 14,304 has been used for the activation of extracellular signal-regulated kinase (ERK) in epicardial coronary artery culture

UK 14,304 has been used in myenteric neurons to study the inhibition of R-type calcium currents. UK 14,304 has also been used for immunofluorescence microscopy assays.

Packaging

5, 25, 100 mg in glass bottle

Biochem/physiol Actions

UK 14,304 is an α2-adrenoceptor agonist. UK 14,304 inhibits hormone-sensitive lipase (HSL) activity and suppresses lipogenesis in adipose tissue.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

UK 14,304 is soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (<0.8 mg/mL), DMSO (>6.5 mg/ml) and ethanol (<8 mg/mL). However, it is insoluble in water.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
1

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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