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U211030 Sigma-Aldrich

DMT-2′O-TBDMS-rU Phosphoramidite

configured for ABI

Synonym: 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-uridine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], DMT-2′-O-TBDMS-rU amidite

  • CAS Number 118362-03-1

  • Empirical Formula (Hill Notation) C45H61N4O9PSi

  • Molecular Weight 861.05

  •  MDL number MFCD00080343

  •  PubChem Substance ID 329827597

  •  NACRES NA.51

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Properties

Related Categories Chemical Synthesis, DMT-2′O-TBDMS-rU Phosphoramidite, Fast Deprotection 2′O-TBDMS RNA Phosphoramidites, Phosphoramidites and Reagents for Oligonucleotide Synthesis (Proligo Reagents), RNA Phosphoramidites,
Quality Level   200
biological source   non-animal source (no BSE/TSE risk)
product line   Proligo Reagents
assay   ≥99% (31P-NMR)
  ≥99.0% (reversed phase HPLC)
  conforms (1H-NMR)
  conforms (LC/MS)
form   powder
application(s)   oligo synthesis: suitable
impurities   ≤0.3% water content (Karl Fischer)
  ≤0.5% P(III) Impurities 100-169ppm (31P-NMR)
  ≤0.5% single Impurity (reversed phase HPLC)
  ≤3% residual Solvent content
color   white to off-white
λ   conforms (UV/VIS Identity)
compatibility   configured for ABI
nucleoside profile   base: uridine
base protecting group: none
2' protecting group: TBDMS
5' protecting group: DMT
deprotection: fast/standard
storage temp.   −20°C
SMILES string   COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=CC(=O)NC3=O)(c4ccccc4)c5ccc(OC)cc5
InChI   1S/C45H61N4O9PSi/c1-31(2)49(32(3)4)59(55-29-15-27-46)57-40-38(56-42(48-28-26-39(50)47-43(48)51)41(40)58-60(10,11)44(5,6)7)30-54-45(33-16-13-12-14-17-33,34-18-22-36(52-8)23-19-34)35-20-24-37(53-9)25-21-35/h12-14,16-26,28,31-32,38,40-42H,15,29-30H2,1-11H3,(H,47,50,51)/t38-,40-,41-,42-,59?/m1/s1
InChI key   SKNLXHRBXYGJOC-ZMHKPELYSA-N
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

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