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U211130 Sigma-Aldrich

DMT-2′O-Methyl-rU Phosphoramidite

configured for ABI

Synonym: 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-uridine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], DMT-2′O-Methyl-rU amidite

  • CAS Number 110764-79-9

  • Empirical Formula (Hill Notation) C40H49N4O9P

  • Molecular Weight 760.81

  •  MDL number MFCD00792626

  •  PubChem Substance ID 329827607

  •  NACRES NA.51

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Properties

Related Categories Chemical Synthesis, DMT-2′O-Methyl-rU Phosphoramidite, Fast Deprotection 2′O-Methyl RNA Phosphoramidites, Phosphoramidites and Reagents for Oligonucleotide Synthesis (Proligo Reagents), RNA Phosphoramidites,
Quality Level   200
biological source   non-animal source (no BSE/TSE risk)
product line   Proligo Reagents
assay   ≥99% (31P-NMR)
  ≥99.0% (reversed phase HPLC)
  conforms (1H-NMR)
  conforms (LC/MS)
form   powder
application(s)   oligo synthesis: suitable
impurities   ≤0.1% single unspecified Impurity (reversed phase HPLC)
  ≤0.3% mU2 (reversed phase HPLC, Hydrolysate)
  ≤0.3% mU3 (reversed phase HPLC, DMT-rme)
  ≤0.3% water content (Karl Fischer)
  ≤0.5% P(III) Impurities 100-169ppm (31P-NMR)
  ≤1.0% mU1 (reversed phase HPLC, DMT-rUme-DMT)
  ≤3% residual Solvent content
color   white to off-white
λ   conforms (UV/VIS Identity)
compatibility   configured for ABI
nucleoside profile   base: uridine
base protecting group: none
2' protecting group: methyl
5' protecting group: DMT
deprotection: fast/standard
storage temp.   2-8°C
SMILES string   CO[C@@H]1[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](COC(c2ccccc2)(c3ccc(OC)cc3)c4ccc(OC)cc4)O[C@H]1N5C=CC(=O)NC5=O
InChI   1S/C40H49N4O9P/c1-27(2)44(28(3)4)54(51-25-11-23-41)53-36-34(52-38(37(36)49-7)43-24-22-35(45)42-39(43)46)26-50-40(29-12-9-8-10-13-29,30-14-18-32(47-5)19-15-30)31-16-20-33(48-6)21-17-31/h8-10,12-22,24,27-28,34,36-38H,11,25-26H2,1-7H3,(H,42,45,46)/t34-,36-,37-,38-,54?/m1/s1
InChI key   UVUOJOLPNDCIHL-XKZJCBTISA-N
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

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