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U2625 Sigma-Aldrich

Uric acid

≥99%, crystalline

Synonym: 2,6,8-Trihydroxypurine

  • CAS Number 69-93-2

  • Empirical Formula (Hill Notation) C5H4N4O3

  • Molecular Weight 168.11

  •  Beilstein/REAXYS Number 156158

  •  EC Number 200-720-7

  •  MDL number MFCD00005712

  •  PubChem Substance ID 24900634

  •  NACRES NA.55

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Properties

Related Categories Cell Biology, Core Bioreagents, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Metabolomics,
InChI Key   LEHOTFFKMJEONL-UHFFFAOYSA-N
Quality Level   100
assay   ≥99%
form   crystalline
mp   >300 °C (lit.)

Description

Application

Uric acid has been used:
• in inducing hyperuricemia in mice
• as a component of digestion fluid for the simulation of in vitro human digestion model
• in selectivity test of the glucose sensor in sweat-based diabetes monitoring

Packaging

1 kg in poly bottle

25, 100 g in poly bottle

Biochem/physiol Actions

Uric acid is an insoluble catabolite produced by adenine and guanine metabolism. Accumulation of uric acid leads to gout, hyperuricemia, arthritis and renal failure. Elevated uric acid levels contributes to hypertension and pathogenesis of cardiovascular disease. Low uric acid levels associated with Parkinson′s disease and multiple sclerosis, may elicit protective functionality. High levels of uric acid in patients with chronic obstructive pulmonary disease (COPD) may serve as potential marker for diagnosis.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Single- & multi-channel pipettes from BRAND
Protocols & Articles

Articles

HPLC Analysis of Caffeine and Metabolites on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Caffeine and Metabolites on Ascentis® RP-Amide
Keywords: Chromatography, Clinical, High performance liquid chromatography

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

TLC Analysis of Purine Derivatives on HPTLC NH2 F254s (analyte set 1)

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Purine Derivatives on HPTLC NH2 F254s (analyte set 1)
Keywords: Thin layer chromatography

TLC Analysis of Purine Derivatives on HPTLC NH2 F254s (analyte set 2)

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Purine Derivatives on HPTLC NH2 F254s (analyte set 2)
Keywords: Thin layer chromatography

Related Content

Uric Acid in Cell Culture

Importance and uses of uric acid (urate) precursors in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures
Keywords: Apoptosis, Cell culture, Culture media, High performance liquid chromatography, Lipid peroxidation, Nitrations, Oxidations, Peroxidations, Reductions

Peer-Reviewed Papers
15

References

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