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UC429 Sigma-Aldrich

Midazolam hydrochloride

solid

Synonym: 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Drug and Xenobiotic Metabolism,
form   solid
drug control   USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
color   white to off-white
solubility   H2O: soluble at least 1 mg/mL
storage temp.   2-8°C
SMILES string   Cc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4-n12
InChI   1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3
InChI key   DDLIGBOFAVUZHB-UHFFFAOYSA-N
Gene Information   human ... ABCB1(5243), CYP3A4(1576), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879)
mouse ... Abcb1a(18671), Abcb1b(18669)
rat ... Gabbr1(81657), Gabra1(29705)

Description

Application

Midazolam has been used as an anesthetic for surgical experiments in rats. This anesthetic has also been used in rats to study the interactions between midazolam and bupivacaine.

Biochem/physiol Actions

Sedative/hypnotic; ligand for the GABAA receptor benzodiazepine modulatory site; CYP3A4 substrate.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Midazolam hydrochloride is soluble in water to at least 1 mg/ml. Product solutions should be protected from light.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. UC429.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
NI2922250

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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