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UC455 Sigma-Aldrich

3-Cyano-7-ethoxycoumarin

≥97% (HPLC)

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, CI-CZ, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   200
assay   ≥97% (HPLC)
color   yellow to orange
storage temp.   2-8°C
SMILES string   CCOc1ccc2C=C(C#N)C(=O)Oc2c1
InChI   1S/C12H9NO3/c1-2-15-10-4-3-8-5-9(7-13)12(14)16-11(8)6-10/h3-6H,2H2,1H3
InChI key   YAFGHMIAFYQSCF-UHFFFAOYSA-N

Description

General description

3-Cyano-7-ethoxycoumarin is a fluorescent substrate for Cytochrome P450 1A1 (CYP1A1), Cytochrome P450 1A2 (CYP1A2), Cytochrome P450 2C9 (CYP2C9) and Cytochrome P450 2C19 (CYP2C19).

Application

3-Cyano-7-ethoxycoumarin has been used as a substrate in cytochrome P (CYP) inhibition for fluorescence measurement.

Packaging

5, 10 mg in glass bottle

Biochem/physiol Actions

Fluorescent probe useful in microsomal dealkylase studies. Typical drug-drug interactions resulting from enzyme inhibition.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

3-Cyano-7-ethoxycoumarin is soluble in DMSO.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers
15

References

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