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V0627 Sigma-Aldrich

Valinomycin

≥98% (TLC), ≥96% (HPLC)

Synonym: Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid

  • CAS Number 2001-95-8

  • Empirical Formula (Hill Notation) C54H90N6O18

  • Molecular Weight 1111.32

  •  Beilstein/REAXYS Number 78657

  •  EC Number 217-896-6

  •  MDL number MFCD00005114

  •  PubChem Substance ID 24900697

  •  NACRES NA.77

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application, Antibiotics by Mechanism of Action,
InChI Key   FCFNRCROJUBPLU-RPUZOQEISA-N
Quality Level   PREMIUM
assay   ≥96% (HPLC)
  ≥98% (TLC)
form   powder
color   white
solubility   DMSO: ≥50 mg/mL
  H2O: insoluble
Mode of action   cell membrane | interferes
antibiotic activity spectrum   Gram-positive bacteria
  parasites
  viruses
storage temp.   2-8°C

Description

General description

Chemical structure: peptide

Biochem/physiol Actions

K+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction.

Packaging

10MG,25MG,100MG,500MG

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGI
WGK Germany 
3
RTECS 
YV9468000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Ion Channels Research

Ion transport across the relatively impermeable lipid bilayer of the cell membrane is accomplished via membrane proteins known as ion channels, pumps and transporters. Ion channels are gated pores an...
Keywords: Biological processes, Cell signaling, Diseases, Hormones, Ligands, Neurotransmitters

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Antibiotics Selection Guide

The Antibiotic Selection Guide enables researchers to spend more time on their research discoveries and less time seeking established antibiotic information. Link to hundreds of antibiotics for conta...
Keywords: Antibiotics, Cell biology, Cell culture, Genetic, High performance liquid chromatography, Reversed-phase chromatography

Peer-Reviewed Papers
15

References

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