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V1005 Sigma-Aldrich

[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate

≥95% (HPLC)

Synonym: DDAVP, Desmopressin

  • CAS Number 16679-58-6 (free base)

  • Empirical Formula (Hill Notation) C46H64N14O12S2 · xC2H4O2 · yH2O

  • Molecular Weight 1069.22 (anhydrous free base basis)

  •  PubChem Substance ID 329829026

  •  NACRES NA.32

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Oxytocin & Vasopressin,
InChI Key   KWCKGAOCVGPZIC-VCCVNBJCSA-N
Quality Level   200
assay   ≥95% (HPLC)
solubility   H2O: soluble 20 mg/mL, clear, colorless
storage temp.   −20°C
Gene Information   human ... AVPR2(554)
mouse ... AVPR2(12000)
rat ... AVPR2(25108)

Description

Amino Acid Sequence

Mpa-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 [Disulfide Bridge: 1-6]

Application

[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate has been used:
• in induction of antidiuresis
• as agonist of V2-receptor (V2R)
• for Von Willebrand factor (VWF) secretion in bleeding diathesis

[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate was used to study the impact of vasopressin on pendrin abundance. E3 ubiquitin (Ub)-protein ligases (E3s) was administered in rat kidney and the changes in protein abundance of the selected E3s in response to [deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate was examined.

Biochem/physiol Actions

[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate also known as DDAVP, Desmopressin is a selective and potent vasopressor agent that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock. It also stimulate three acid-base transporters and hence increases the capability of the cell to regulate pH.

Preparation Note

[deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate dissolves in water at 20 mg/ml to yield a clear, colorless solution.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

LC/MS Analysis of Polypeptide Drugs on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Polypeptide Drugs on Ascentis® Express RP-Amide
Keywords: Chromatography, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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