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V1377 Sigma-Aldrich

Vinblastine sulfate salt

≥97% (HPLC)

Synonym: VLB, Vincaleukoblastine sulfate salt

  • CAS Number 143-67-9

  • Empirical Formula (Hill Notation) C46H58N4O9 · H2SO4

  • Molecular Weight 909.05

  •  Beilstein/REAXYS Number 3659812

  •  EC Number 205-606-0

  •  MDL number MFCD00082457

  •  PubChem Substance ID 24278771

  •  NACRES NA.77



Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application,
Quality Level   200
assay   ≥97% (HPLC)
form   (powder or amorphous or crystalline powder)
color   white to light yellow
mp   267 °C (dec.) (lit.)
absorption   14 at 270 nm in 0.1 M phosphate buffer at 1 mM
  16.2 at 259 nm in ethanol at 1 mM
  53.7 at 214 nm in ethanol at 1 mM
Mode of action   DNA synthesis | interferes
antibiotic activity spectrum   neoplastics
originator   Eli Lilly
storage temp.   2-8°C
SMILES string   OS(O)(=O)=O.[H][C@@]12CN(CCc3c([nH]c4ccccc34)[C@@](C1)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@@]7([H])[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67[C@]89[H])C(=O)OC)C[C@](O)(CC)C2
InChI   1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1
Gene Information   human ... TBCC(6903), TUBA1A(7846), TUBA1B(10376), TUBA1C(84790), TUBA3C(7278), TUBA3E(112714), TUBA4A(7277), TUBB(203068), TUBB1(81027), TUBB2A(7280), TUBB2B(347733), TUBB3(10381), TUBB4A(10382), TUBB4B(10383), TUBB6(84617), TUBB8(347688)



Vinblastine sulfate salt has been used:
• as a microtubule depolymerizing drug for the synchronization of human cell lines in G2/M phase
• as a multidrug resistance screening substrate in human colon cancer cell line (HCT116) cell line
• as an antimicrotubule agent in sub perineural glia of Drosophila brain

Biochem/physiol Actions

Plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing self-association in spiral aggregates in a reaction that appears to be regulated by the C-terminus of β-tubulin and is enhanced by GDP and GTP. Depolymerizes microtubules. Arrests the cell cycle in G2/M-phase by blocking mitotic spindle formation. Triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. Substrate of Pgp and CYP3A4.

Features and Benefits

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This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

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Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Precautionary statements 
NONH for all modes of transport
WGK Germany 


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


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