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W1020 Sigma-Aldrich

W146 hydrate

≥98% (HPLC)

Synonym: ML056, R-3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid hydrate, [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   DQKSZHVSROOTFY-XFULWGLBSA-N
assay   ≥98% (HPLC)
form   powder
color   off-white
solubility   methanol: soluble (with 0.1% TFA)
originator   Novartis
storage temp.   2-8°C

Description

Biochem/physiol Actions

Potent S1P(1) competitive antagonist; Ki = 10-77 nM.

Packaging

1, 5 mg in glass bottle

Application

W146 hydrate has been used to assess vascular permeability in mice.

Features and Benefits

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

W146 hydrate functions as an orthosteric antagonist. It is associated with blood lymphopenia and lung edema in mice.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Lipid Signaling Research

Within mammalian cells, a multitude of lipid compounds are found with a variety of cellular functions, including structural components of cell membranes and as second messengers in cell signaling pat...
Keywords: Absorption, Atomic absorption spectroscopy, Cancer, Cardiovascular, Cell signaling, Diabetes, Digestions, Diseases, Growth factors, Hormones, Inflammation, Lipid Metabolism, Lipid signaling, Metabolism

Lysophospholipid Receptors

Although historically considered as intermediates in the biosynthesis of glycerophospholipids and the degradation of sphingolipids, the lysophospholipids lysophosphatidic acid (LPA) and sphingosine 1...
Keywords: Atomic absorption spectroscopy, Cancer, Chemical biology, Degradations, Gene expression, Genetic, Genetics, Ligands, Phosphorylations, Transduction

Peer-Reviewed Papers
15

References

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