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W4262 Sigma-Aldrich

1400W dihydrochloride

>98%, solid

Synonym: N-([3-(Aminomethyl)phenyl]methyl)ethanimidamide dihydrochloride

  • CAS Number 214358-33-5

  • Empirical Formula (Hill Notation) C10H15N3 · 2 HCl

  • Molecular Weight 250.17

  •  MDL number MFCD03428622

  •  PubChem Substance ID 24278778

  •  NACRES NA.77

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Properties

Related Categories Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
Quality Level   100
assay   >98%
form   solid
storage condition   desiccated
originator   GlaxoSmithKline
shipped in   wet ice
storage temp.   −20°C
SMILES string   Cl[H].Cl[H].CC(=N)NCc1cccc(CN)c1
InChI   1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
InChI key   WDJHSQZCZGPGAA-UHFFFAOYSA-N
Gene Information   human ... NOS1(4842), NOS2(4843), NOS3(4846)

Description

Application

1400W dihydrochloride has been used:
• as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat
• as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction
• to study its efficacy on renal ischemia/ reperfusion injury in rats
• as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation

Packaging

10 mg in glass bottle

Biochem/physiol Actions

1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS).

Features and Benefits

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Exposure to harsh conditions, cellular damage, and other factors can cause stress on cells. Stress attributed directly and indirectly to oxygen is referred to as oxidative stress, which is imposed on...
Keywords: Antimicrobials, Bioactive small molecules, Cancer, Diseases, Neurodegenerative Diseases, Oxidations

Peer-Reviewed Papers
15

References

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