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  • WH0007345M1 - Monoclonal Anti-UCHL1 antibody produced in mouse

WH0007345M1 Sigma-Aldrich

Monoclonal Anti-UCHL1 antibody produced in mouse

clone 1B8-4D2, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-PARK5, Anti-PGP9.5, Anti-ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

  •  NACRES NA.41



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Parkinson’s Disease Research, Antibodies to Protein Degradation,
conjugate   unconjugated
clone   1B8-4D2, monoclonal
biological source   mouse
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
  indirect ELISA: suitable
  western blot: 1-5 μg/mL
species reactivity   rat, mouse, human
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   purified immunoglobulin
isotype   IgG1κ
Quality Level   100
antibody product type   primary antibodies
GenBank® accession no.   BC000332
UniProt accession no.   P09936
Gene Information   human ... UCHL1(7345)


General description

Ubiquitin C-terminal hydrolase L1 (UCHL1) is encoded by the gene mapped to human chromosome 4p14. The encoded protein is a deubiquitinase, which is part of the ubiquitin proteasome system (UPS). UCHL1 is specifically expressed in the nervous system and gonads.


UCHL1 (AAH00332, 1 a.a. ~ 223 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.


Physical form

Solution in phosphate buffered saline, pH 7.4


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Biochem/physiol Actions

Ubiquitin C-terminal hydrolase L1 (UCHL1) catalyzes the hydrolysis of carboxy-terminal ubiquitin esters and amides. It plays an essential role in epithelial-mesenchymal transition. In addition, UCHL1 is also implicated in the cell invasion and in the cell cycle regulation. UCHL1 gene acts as an oncogene in various types of cancers including glioma, gastric cardiac adenocarcinoma (GCA) and colorectal cancer. It also acts as a susceptibility gene for Parkinson′s disease.

Safety & Documentation

Safety Information

NONH for all modes of transport
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy


Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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