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  • WH0056137M2 - Monoclonal Anti-PCDHA12 antibody produced in mouse

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WH0056137M2 Sigma-Aldrich

Monoclonal Anti-PCDHA12 antibody produced in mouse

clone 1D3, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-MGC138485, Anti-PCDHALPHA12, Anti-protocadherin alpha 12

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Properties

Related Categories Alphabetical Index, Antibodies, PB-PC, Primary Antibodies
species reactivity   human
application(s)   indirect ELISA: suitable
clone   1D3, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG2bκ
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... PCDHA12(56137)
biological source   mouse
antibody product type   primary antibodies
conjugate   unconjugated
GenBank® accession no.   NM_018903
UniProt accession no.   Q9UN75

Description

Immunogen

PCDHA12 (NP_061726, 222 a.a. ~ 327 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
LTGSVQIQITVLDVNDNGPAFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPVSEKCMFSINPDTGEIRIYGELDFEENNAYEIQVNAIDKGI

General description

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. (provided by RefSeq)

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

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Safety & Documentation

Safety Information

Personal Protective Equipment  Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RIDADR  NONH for all modes of transport
WGK Germany  nwg
Protocols & Articles

Articles

Antibody Basics

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