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Y102 Sigma-Aldrich

YC-1

powder

Synonym: 3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl indazole

  • CAS Number 170632-47-0

  • Empirical Formula (Hill Notation) C19H16N2O2

  • Molecular Weight 304.34

  •  MDL number MFCD06407798

  •  PubChem Substance ID 24278782

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism,
Quality Level   200
form   powder
color   white to yellow
solubility   DMSO: 10 mg/mL
  H2O: insoluble
SMILES string   OCc1ccc(o1)-c2nn(Cc3ccccc3)c4ccccc24
InChI   1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
InChI key   OQQVFCKUDYMWGV-UHFFFAOYSA-N
Gene Information   human ... PDE5A(8654)

Description

Application

YC-1 has been used as a hypoxia-inducible factor 1α (HIF-1α) inhibitor:
• to reduce hypoxia induced Jagged1 expression in cardiomyocytes (CMs)
• to study its effect on progenitor expansion and CD34+ and side population (SP) cell phenotype and on the proliferation rate of cells with an ability to form long term colony forming units
• to study its effect on regulating sphingosine 1-phosphate (S1P) bound to albumin induced plasminogen activator inhibitor 1 (PAI-1) expression by activating Rho/ Rho-associated protein kinase (ROCK) pathway.

Packaging

25 mg in glass insert

5 mg in glass bottle

Biochem/physiol Actions

NO (nitric oxide)-independent activator of soluble guanylyl cyclase.

YC-1 activates soluble guanylyl cyclase and prevents platelet aggregation and vascular contraction. It has a potential to treat circulation disorders. YC-1 also has an ability to inhibit hypoxia-inducible factor 1α (HIF-1α) activity in vitro. It acts as a potential antiangiogenic anticancer agent.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cyclic Nucleotides

Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c...
Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters

Peer-Reviewed Papers
15

References

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