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Z3003 Sigma-Aldrich

Zardaverine

phosphodiesterase inhibitor

Synonym: 6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone

  • CAS Number 101975-10-4

  • Empirical Formula (Hill Notation) C12H10F2N2O3

  • Molecular Weight 268.22

  •  MDL number MFCD00867059

  •  PubChem Substance ID 24278784

  •  NACRES NA.77

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, Enzyme Inhibitors,
potency   1.1 μM IC50 (for PDE IV)
  2.5 μM IC50 (for PDE III)
SMILES string   COc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2
InChI   1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)
InChI key   HJMQDJPMQIHLPB-UHFFFAOYSA-N
Gene Information   human ... PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE7A(5150)
rat ... Pde2a(81743), Pde4a(25638)

Description

Biochem/physiol Actions

Selective inhibitor of phosphodiesterase III/IV (PDE3/4).

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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