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Z3003 Sigma-Aldrich

Zardaverine

phosphodiesterase inhibitor

Synonym: 6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone

  • CAS Number 101975-10-4

  • Empirical Formula (Hill Notation) C12H10F2N2O3

  • Molecular Weight 268.22

  •  MDL number MFCD00867059

  •  PubChem Substance ID 24278784

  •  NACRES NA.77

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, Enzyme Inhibitors,
biological source   synthetic (organic)
assay   ≥98% (HPLC)
form   powder
potency   1.1 μM IC50 (for PDE IV)
  2.5 μM IC50 (for PDE III)
SMILES string   COc1cc(ccc1OC(F)F)C2=NNC(=O)C=C2
InChI   1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)
InChI key   HJMQDJPMQIHLPB-UHFFFAOYSA-N
Gene Information   human ... PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144), PDE5A(8654), PDE7A(5150)
rat ... Pde2a(81743), Pde4a(25638)

Description

Biochem/physiol Actions

Selective inhibitor of phosphodiesterase III/IV (PDE3/4).

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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