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00922 Supelco

Difluoroacetic acid

for LC-MS LiChropur, ≥97.5% (GC)

Synonym: DFA

  • CAS Number 381-73-7

  • Linear Formula F2CHCO2H

  • Molecular Weight 96.03

  •  Beilstein/REAXYS Number 1098588

  •  MDL number MFCD00004220

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Chromatography Reagents & Solvents, LC-MS Additives & Reagents, LC-MS Mobile Phase Additives,
assay   ≥97.5% (GC)
  97.5-102.5% (T)
application(s)   HPLC: suitable
refractive index   n20/D 1.344 (lit.)
bp   132-134 °C (lit.)
mp   −1 °C (lit.)
density   1.526 g/mL at 25 °C (lit.)
cation traces   Al: ≤5 ppm
  Ca: ≤20 ppm
  Cu: ≤5 ppm
  Fe: ≤2 ppm
  K: ≤50 ppm
  Mg: ≤5 ppm
  Na: ≤50 ppm
suitability   passes test for LC-MS
SMILES string   OC(=O)C(F)F
InChI   1S/C2H2F2O2/c3-1(4)2(5)6/h1H,(H,5,6)
InChI key   PBWZKZYHONABLN-UHFFFAOYSA-N

Description

General description

Compared to trifluoroacetic acid (TFA), difluoroacetic acid (DFA) exhibits an improved sensitivity in mass spectral detection (ESI) as it has a reduced effect on ion suppression in reversed-phase liquid chromatography (RPLC-MS), while keeping its strong chromatographic performance enhancing effects.

Packaging

Clear borosilicate glass, high hydrolytic resistance (Type I)

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Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
WGK Germany 
WGK 3
RTECS 
AG9900000
Flash Point(F) 
172.4 °F - closed cup
Flash Point(C) 
78 °C - closed cup

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

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