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11024AST Supelco

Astec® CHIROBIOTIC® V Chiral HPLC Column

5 μm particle size, L × I.D. 25 cm × 4.6 mm

  •  eCl@ss 32110501

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Properties

Related Categories Analytical/Chromatography, Astec CHIROBIOTIC Chiral HPLC Columns (Macrocyclic Glycopeptides), Astec CHIROBIOTIC V Chiral HPLC Columns, CHIROBIOTIC V, Chiral HPLC Columns,
description   HPLC Column
packaging   pkg of 1 ea
mfr. no.   Astec
parameter   0-45 °C temperature
  241 bar pressure (3500 psi)
application(s)   HPLC: suitable
L × I.D.   25 cm × 4.6 mm
matrix   High-purity silica gel particle platform
matrix active group   vancomycin phase
particle size   5 μm
pore size   100 Å
operating pH range   3.5 - 7.0
separation technique   chiral

Description

General description

Neutral molecules, amides, acids, esters and amines show considerable enantioselectivity on these vancomycin-based CSPs. A wide variety of secondary and tertiary amines have been separated on the CHIROBIOTIC® V in the polar ionic mode. The CHIROBIOTIC® V has demonstrated many of the separation characteristics of protein-based stationary phases, but with exceptional stability and much higher sample capacity. Some chiral analytes have been resolved that have not been reported separated on any other chiral stationary phase. CHIROBIOTIC® V and V2 differ in their bonding chemistry the pore size of the support particle, giving them different selectivity and preparative capacity.

• Bonded phase: Vancomycin
• Operating pH range: 3.5 - 7.0
• Particle diameter: 5, 10 or 16 μm
• Pore size: 100 Å (CHIROBIOTIC® V) or 200 Å (CHIROBIOTIC® V2)

Application

Astec® CHIROBIOTIC® V Chiral HPLC column may be used for the separation of different types of racemic compounds (ß-blockers, ß-agonists, benzodiazipines, non-steroidal anti-inflammatory drugs, barbiturates, free and derivatized amino acids in packed column subcritical fluid chromatography (pSFC). It may also be used for the separation of citalopram enantiomers and its two N-demethylated metabolites and of alprenolol that is the internal standard, in human plasma using chiral liquid chromatography. It may also be used in the chiral liquid chromatography analysis of ketoprofen and flurbiprofen.

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Legal Information

Astec is a registered trademark of Sigma-Aldrich Co. LLC

CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

HPLC Analysis of 3,5-tBu-MeOBIPHEP Enantiomers on Astec® CHIROBIOTIC® V in Normal Phase and Polar Ionic Modes

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of 3,5-tBu-MeOBIPHEP Enantiomers on Astec® CHIROBIOTIC® V in Normal Phase and Polar Ionic Modes
Keywords: Chromatography, High performance liquid chromatography, Ligands

HPLC Analysis of 3,5-tBu-MeOBIPHEP Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of 3,5-tBu-MeOBIPHEP Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of 3a,4,5,6-Tetrahydrosuccinimido[3,4-b]acenaphthen-10-one Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of 3a,4,5,6-Tetrahydrosuccinimido[3,4-b]acenaphthen-10-one Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of 5-Methyl-5-Phenylhydantoin Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of 5-Methyl-5-Phenylhydantoin Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Benoxaprofen Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Benoxaprofen Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Benzoin Methyl Ether Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Benzoin Methyl Ether Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Vitamins

HPLC Analysis of Bupivacaine Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Bupivacaine Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Chloroquine Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Chloroquine Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Citalopram Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Citalopram Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Anti-depressants, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Clenbuterol Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Clenbuterol Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Antihypertensives, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Coumachlor Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Coumachlor Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, Environmental, Herbicides, High performance liquid chromatography, Pesticides, Pharmaceutical

HPLC Analysis of Coumafuryl Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Coumafuryl Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, Environmental, Herbicides, High performance liquid chromatography, Pesticides

HPLC Analysis of Devrinol (Napropamide) Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Devrinol (Napropamide) Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, Environmental, Herbicides, High performance liquid chromatography, Pesticides

HPLC Analysis of Fenoprofen Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fenoprofen Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Fenoprofen Methyl Ester Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fenoprofen Methyl Ester Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Fenoterol Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Fenoterol Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Flurbiprofen Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Flurbiprofen Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Hydroxychloroquine Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Hydroxychloroquine Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Ibuprofen Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Ibuprofen Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Indoprofen Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Indoprofen Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Isopromethazine Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Isopromethazine Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Ketoprofen Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Ketoprofen Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Labetalol Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Labetalol Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Antihypertensives, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Luciferin Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Luciferin Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Methylphenidate Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Methylphenidate Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Methylphenobarbital (Mephobarbital) Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Methylphenobarbital (Mephobarbital) Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical, Separation, Solvents

HPLC Analysis of Metoprolol Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Metoprolol Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Antihypertensives, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Mosapride Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Mosapride Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Naproxen Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Naproxen Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Nicardipine Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Nicardipine Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Antihypertensives, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Phensuximide Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Phensuximide Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Proglumide Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Proglumide Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Promethazine Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Promethazine Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Promethazine Sulfoxide Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Promethazine Sulfoxide Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Pyroglutethimide Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Pyroglutethimide Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Antitumor agents, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Sibutramine Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Sibutramine Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, Clinical, High performance liquid chromatography, Mass spectrometry, Obesity, Pharmaceutical

HPLC Analysis of Sotalol Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Sotalol Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Antihypertensives, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Thalidomide Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Thalidomide Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Warfarin™ Enantiomers on Astec® CHIROBIOTIC® V (Method 1)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Warfarin™ Enantiomers on Astec® CHIROBIOTIC® V (Method 1)
Keywords: Anticoagulants, Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Warfarin™ Enantiomers on Astec® CHIROBIOTIC® V (Method 2)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Warfarin™ Enantiomers on Astec® CHIROBIOTIC® V (Method 2)
Keywords: Anticoagulants, Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Warfarin™ Enantiomers on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Warfarin™ Enantiomers on Astec® CHIROBIOTIC® V
Keywords: Anticoagulants, Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of α-Methylbenzylamine Enantiomers (3,5-Dinitrobenzoyl Derivatives) on Astec® CHIROBIOTIC® V

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of α-Methylbenzylamine Enantiomers (3,5-Dinitrobenzoyl Derivatives) on Astec® CHIROBIOTIC® V
Keywords: Chromatography, High performance liquid chromatography

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Peer-Reviewed Papers
15

References

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