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47869 Supelco

Cyanocobalamin (B12)

analytical standard

Synonym: α-(5,6-Dimethylbenzimidazolyl)cyanocobamide, CN-Cbl, Cyanocob(III)alamin, Cyanocobalamin, Vitamin B12

  • CAS Number 68-19-9

  • Empirical Formula (Hill Notation) C63H88CoN14O14P

  • Molecular Weight 1355.37

  •  Beilstein/REAXYS Number 4122889

  •  EC Number 200-680-0

  •  PubChem Substance ID 24871566

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Application Areas and Market Segments, Biochemicals and Reagents,
grade   analytical standard
form   neat
packaging   ampule of 100 mg
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   > 300 °C (decomposes before melting)
Featured Industry   Pharmaceutical (small molecule)
Vitamins, Nutraceuticals, and Natural Products
format   neat
storage temp.   2-8°C
SMILES string   C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@
InChI   1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1
InChI key   RMRCNWBMXRMIRW-QJRSUKKJSA-L

Description

General description

Cyanocobalamin (B12) is a water soluble vitamin, which belongs to the B12 class of vitamins, commonly called as cobalamins.(1) It is mainly found in animal products such as dairy products, meat and also eggs. It can find applications in the preparation of multivitamin supplements and fortified food. It works as a coenzyme to convert L-methylmalonyl CoA to succinyl CoA, which is catalyzed by isomerase.

Application

Cyanocobalamin (B12) may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations and food products by various chromatography techniques.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 47869.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
GG3750000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of B-Vitamins in Vitamin Water using Ascentis® Express RP-Amide and UV Detection

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of B-Vitamins in Vitamin Water using Ascentis® Express RP-Amide and UV Detection
Keywords: Anticonvulsants, Chromatography, Pharmaceutical, Vitamins

HPLC Analysis of B-vitamins on Ascentis® Express RP-Amide using UV detection

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of B-vitamins on Ascentis® Express RP-Amide using UV detection
Keywords: Anticonvulsants, Chromatography, Pharmaceutical, Vitamins

HPLC Analysis of Water Soluble B Vitamins on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Water Soluble B Vitamins on Ascentis® Express RP-Amide
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical, Vitamins

HPLC Analysis of Water-Soluble B-Vitamins on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Water-Soluble B-Vitamins on Ascentis® Express C18
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical, Vitamins

HPLC Analysis of Water-Soluble B-Vitamins on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Water-Soluble B-Vitamins on Ascentis® Express F5
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical, Vitamins

TLC Analysis of Vitamins on HPTLC NH2 F254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Vitamins on HPTLC NH2 F254s
Keywords: Thin layer chromatography, Vitamins

UHPLC Analysis of B Vitamins in Vitamin Water on Titan™ C18 using UV Detection

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of B Vitamins in Vitamin Water on Titan™ C18 using UV Detection
Keywords: Anticonvulsants, Chromatography, Pharmaceutical, Vitamins

UHPLC Analysis of B-vitamins on Titan™ C18 using UV detection

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of B-vitamins on Titan™ C18 using UV detection
Keywords: Anticonvulsants, Chromatography, Pharmaceutical, Vitamins

Peer-Reviewed Papers
15

References

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