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47889 Supelco

Methyl Paraben

analytical standard

Synonym: p-Hydroxybenzoic acid methyl ester, Methyl 4-hydroxybenzoate, Methyl paraben, NIPAGIN

  • CAS Number 99-76-3

  • Linear Formula HOC6H4CO2CH3

  • Molecular Weight 152.15

  •  Beilstein/REAXYS Number 509801

  •  EC Number 202-785-7

  •  MDL number MFCD00002352

  •  PubChem Substance ID 24871585

  •  E Number E218

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Antioxidants & Preservatives, E numbers (Food Additives), E200–E299 (preservatives),
grade   analytical standard
InChI Key   LXCFILQKKLGQFO-UHFFFAOYSA-N
form   neat
packaging   ampule of 1000 mg
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
mp   125-128 °C (lit.)
Featured Industry   Cosmetics, Personal Care, and Cleaning Products
Food and Beverages
format   neat
storage temp.   room temp
Gene Information   rat ... Ar(24208)

Description

General description

Methyl Paraben is a stable, non-volatile, methyl ester of p-hydroxybenzoic acid. It can find applications as a broad-spectrum antimicrobial preservative in foods, drugs and cosmetics. It is found to be noncarcinogenic and is highly effective against fungi like molds and yeast as well as bacteria.

Methyl paraben is basically a methyl ester of p-hydroxybenzoic acid. It is non-toxic, and non-carcinogenic in nature. It is a stable, non-volatile compound and finds application as an anti-microbial preservative in foods, drugs and cosmetics. It is readily absorbed through the skin and gastrointestinal tract. Upon hydrolyzation, it is hydrolyzed to p-hydroxybenzoic acid, and the conjugates formed get rapidly excreted in the urine.

Application

Methyl paraben was used a preservative standard in commercial food products, during an experimental investigation, done to study the application of microemulsion electrokinetic chromatography (MEEKC), in detecting food preservatives.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Safety & Documentation

Safety Information

Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
DH2450000

Documents

Certificate of Analysis

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How is Product No. 47889 EPA 8040A Phenol Calibration Mix packaged?
Product No. 47889 comes packaged in a 4ml amber vial with teflon lined solid cap.
What is Product No. 47889 EPA 8040A Phenol Calibration Mix soluble in?
Product No. 47889 EPA 8040A Phenol Calibration Mix is slightly soluble in water and soluble in alcohol, diethyl ether, and acetone
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
My question is not addressed here, how can I contact Technical Service for assistance?
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Protocols & Articles

Articles

GC Analysis of Parabens on SLB®-5ms after SPME using 50/30 μm DVB/Carboxen/PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Parabens on SLB®-5ms after SPME using 50/30 μm DVB/Carboxen/PDMS Fiber
Keywords: Antimicrobials, Chromatography, Gas chromatography, Pharmaceutical, Purification, Solid phase microextractions

HPLC Analysis of Cosmetic Preservatives on Ascentis® Express C18 (0.6 mL/min)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Cosmetic Preservatives on Ascentis® Express C18 (0.6 mL/min)
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

HPLC Analysis of Cosmetic Preservatives on Ascentis® Express C18 (1.2 mL/min)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Cosmetic Preservatives on Ascentis® Express C18 (1.2 mL/min)
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

HPLC Analysis of Cosmetic Preservatives on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Cosmetic Preservatives on Ascentis® Express RP-Amide
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

HPLC Analysis of Paraben Preservatives on Discovery® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Paraben Preservatives on Discovery® C18
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

HPLC Analysis of Paraben Preservatives on Discovery® C8

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Paraben Preservatives on Discovery® C8
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

HPLC Analysis of Paraben Preservatives on Discovery® Cyano

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Paraben Preservatives on Discovery® Cyano
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Paraben Preservatives on Discovery® RP-AmideC16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Paraben Preservatives on Discovery® RP-AmideC16
Keywords: Chromatography, Cosmetics, High performance liquid chromatography

HPLC analysis of Methyl Paraben and Organic Acids on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC analysis of Methyl Paraben and Organic Acids on Ascentis® Express RP-Amide
Keywords: Chromatography, High performance liquid chromatography

Peer-Reviewed Papers
15

References

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