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Chloroform

analytical standard

Synonym: Methylidyne trichloride, Trichloromethane

  • CAS Number 67-66-3

  • Empirical Formula (Hill Notation) CHCl3

  • Molecular Weight 119.38

  •  Beilstein/REAXYS Number 1731042

  •  EC Number 200-663-8

  •  MDL number MFCD00000826

  •  PubChem Substance ID 329757381

  •  NACRES NA.24

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Properties

Related Categories A-C, Analytical Standards, Analytical/Chromatography, Fumigants, Insecticides,
Quality Level   100
grade   analytical standard
vapor density   4.1 (vs air)
vapor pressure   160 mmHg ( 20 °C)
assay   ≥99.8%
form   neat
packaging   ampule of 1000 mg
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
color   colorless
refractive index   n20/D 1.445 (lit.)
bp   60.5-61.5 °C (lit.)
mp   −63 °C (lit.)
density   1.492 g/mL at 25 °C (lit.)
Featured Industry   Agriculture
Environmental
format   neat
storage temp.   room temp
SMILES string   ClC(Cl)Cl
InChI   1S/CHCl3/c2-1(3)4/h1H
InChI key   HEDRZPFGACZZDS-UHFFFAOYSA-N

Description

General description

Chloroform is widely used as an industrial solvent, aerosol propellant and as a preservative in concentrations between 0.1 and 0.5 percent in aqueous pharmaceutical preparations. It is a human carcinogen with cardiotoxic and hepatotoxic effects and is also known to cause skin infections.

Application

Chloroform may be used as an analytical standard for the determination of the analyte in aqueous pharmaceutical formulations by chromatography and drinking water samples by spectrofluorimetry.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
RIDADR 
UN 1888 6.1 / PGIII
WGK Germany 
3
RTECS 
FS9100000

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

GC Analysis of Class 2 Residual Solvents on Equity®-1 after SPME using 85 μm Polyacrylate Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 2 Residual Solvents on Equity®-1 after SPME using 85 μm Polyacrylate Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography, Solid phase microextractions

GC Analysis of Class 2 Residual Solvents on OVI-G43

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 2 Residual Solvents on OVI-G43
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography

GC Analysis of Class 2 Residual Solvents on VOCOL® after SPME using 85 μm Polyacrylate Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Class 2 Residual Solvents on VOCOL® after SPME using 85 μm Polyacrylate Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Size-exclusion chromatography, Solid phase microextractions

GC Analysis of Industrial Solvents on Equity®-1701

From our library of Articles, Sigma-Aldrich presents GC Analysis of Industrial Solvents on Equity®-1701
Keywords: Chromatography, Flame ionization detector, Gas chromatography

GC Analysis of Industrial Solvents on Equity®-1

From our library of Articles, Sigma-Aldrich presents GC Analysis of Industrial Solvents on Equity®-1
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Size-exclusion chromatography

GC Analysis of Industrial Solvents on SUPELCOWAX 10

From our library of Articles, Sigma-Aldrich presents GC Analysis of Industrial Solvents on SUPELCOWAX 10
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification

GC Analysis of Residual Solvents on SPB®-624 after SPME using 100 μm PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Residual Solvents on SPB®-624 after SPME using 100 μm PDMS Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Pharmaceutical, Purification, Sample preparations, Solid phase microextractions

GC Analysis of Volatiles in Water on SPB®-1 after SPME using 100 μm PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Volatiles in Water on SPB®-1 after SPME using 100 μm PDMS Fiber
Keywords: Chromatography, Flame ionization detector, Gas chromatography, Purification, Solid phase microextractions

GC Analysis of Volatiles on SPB®-624, Direct Injection

From our library of Articles, Sigma-Aldrich presents GC Analysis of Volatiles on SPB®-624, Direct Injection
Keywords: Chromatography, Gas chromatography, Purification, Size-exclusion chromatography

GC Analysis of Volatiles on VOCOL® after SPME using 75 μm Carboxen/PDMS Fiber

From our library of Articles, Sigma-Aldrich presents GC Analysis of Volatiles on VOCOL® after SPME using 75 μm Carboxen/PDMS Fiber
Keywords: Chromatography, Gas chromatography, Mass spectrometry, Purification, Size-exclusion chromatography, Solid phase microextractions

GC Analysis of a 12-Component Chlorinated Solvents Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column

From our library of Articles, Sigma-Aldrich presents GC Analysis of a 12-Component Chlorinated Solvents Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column
Keywords: Chromatography, Flame ionization detector, Gas chromatography

GC Analysis of a 56-Component Industrial Solvents Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column

From our library of Articles, Sigma-Aldrich presents GC Analysis of a 56-Component Industrial Solvents Mix on SLB®-IL60, Comparison to a Polyethylene Glycol (PEG) Column
Keywords: Chromatography, Flame ionization detector, Gas chromatography

TLC Analysis of Phenylenediamines on HPTLC Silica Gel 60 F 254 with Concentrating Zone

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Phenylenediamines on HPTLC Silica Gel 60 F 254 with Concentrating Zone

TLC Analysis of Pyrimidine Bases on HPTLC NH2 F254s (analyte set 1)

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Pyrimidine Bases on HPTLC NH2 F254s (analyte set 1)
Keywords: Thin layer chromatography

US EPA Method 502.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap, ELCD Signal

From our library of Articles, Sigma-Aldrich presents US EPA Method 502.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap, ELCD Signal
Keywords: Chromatography, Gas chromatography, Hall electrolytic conductivity detector, Photo-ionization detector, Purge and trap, Sample preparations

US EPA Method 502.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap, PID Signal

From our library of Articles, Sigma-Aldrich presents US EPA Method 502.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap, PID Signal
Keywords: Chromatography, Gas chromatography, Hall electrolytic conductivity detector, Photo-ionization detector, Purification

US EPA Method 524.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap

From our library of Articles, Sigma-Aldrich presents US EPA Method 524.2: GC Analysis of Volatiles on VOCOL® (105 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap
Keywords: Chromatography, Gas chromatography, Purification, Size-exclusion chromatography

US EPA Method 624: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method 624: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis
Keywords: Chromatography, Environmental, Gas chromatography, Purification, Solid phase microextractions

US EPA Method 624: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap

From our library of Articles, Sigma-Aldrich presents US EPA Method 624: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap
Keywords: Chromatography, Environmental, Gas chromatography, Purification, Solid phase microextractions

US EPA Method 624: GC Analysis of Volatiles on VOCOL® (60 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap

From our library of Articles, Sigma-Aldrich presents US EPA Method 624: GC Analysis of Volatiles on VOCOL® (60 m x 0.53 mm I.D.) after Purge & Trap using "K" Trap
Keywords: Chromatography, Gas chromatography, Purification, Size-exclusion chromatography

US EPA Method 8260: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method 8260: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis
Keywords: Chromatography, Gas chromatography, Gas chromatography mass spectrometry, Mass spectrometry, Purge and trap, Purification, Solid phase microextractions

US EPA Method 8260: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap

From our library of Articles, Sigma-Aldrich presents US EPA Method 8260: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap
Keywords: Chromatography, Environmental, Gas chromatography, Purification, Solid phase microextractions

US EPA Method 8260: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method 8260: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap, Fast GC Analysis
Keywords: Chromatography, Gas chromatography, Purification, Solid phase microextractions

US EPA Method 8260: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap

From our library of Articles, Sigma-Aldrich presents US EPA Method 8260: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap
Keywords: Chromatography, Gas chromatography, Purification, Solid phase microextractions

US EPA Method OLM04.2 VOA: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method OLM04.2 VOA: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis
Keywords: Chromatography, Environmental, Gas chromatography, Purification, Solid phase microextractions

US EPA Method OLM04.2 VOA: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap, Fast GC Analysis

From our library of Articles, Sigma-Aldrich presents US EPA Method OLM04.2 VOA: GC Analysis of Volatiles on VOCOL® after Purge & Trap using "K" Trap, Fast GC Analysis
Keywords: Chromatography, Environmental, Gas chromatography, Purification, Solid phase microextractions

US EPA Method TO-17: GC Analysis of Volatiles on Equity®-1 after Collection/Desorption using Carbotrap 300 Tube

From our library of Articles, Sigma-Aldrich presents US EPA Method TO-17: GC Analysis of Volatiles on Equity®-1 after Collection/Desorption using Carbotrap 300 Tube
Keywords: Chromatography, Gas chromatography

US EPA Method TO-17: GC Analysis of Volatiles on VOCOL® after Collection/Desorption using Air Toxics Tube

From our library of Articles, Sigma-Aldrich presents US EPA Method TO-17: GC Analysis of Volatiles on VOCOL® after Collection/Desorption using Air Toxics Tube
Keywords: Air Monitoring, Chromatography, Flame ionization detector, Gas chromatography, Purification

Peer-Reviewed Papers
15

References

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