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53228-U Supelco

SupelMIP® SPE - Amphetamine

bed wt. 25 mg, volume 3 mL, pk of 50



Related Categories Analytical/Chromatography, Sample Preparation & Purification, Solid Phase Extraction (SPE), SupelMIP Molecular Imprinted Polymers, SupelMIP SPE - Amphetamine More...
material   polypropylene tube
composition   bed wt., 25 mg
packaging   pk of 50
volume   3 mL
matrix active group   SupelMIP® phase
Featured Industry   Food and Beverages


General description

SupelMIP SPE phases were developed by MIP Technologies AB, which is one of the leading authorities and commercial pioneers of molecular imprinted polymers for process scale separations, analytical chromatography, and sample preparation.

The SupelMIP SPE line consist s of highly cross-linked polymers that are engineered to extract a single analyte of interest or a class of structurally related analytes with an extremely high degree of selectivity. This is possible because selectivity is introduced during MIP synthesis in which a template molecule, designed to mimic the analyte, guides the formation of specific cavities or imprints that are sterically and chemically complementary to the analyte(s) of interest.

By careful design of the imprinting site, either by molecular modeling, experimental design, or screening methods, the binding cavities can be engineered to offer multiple interaction points with the analyte(s) of interest. This leads to a stronger interaction between the solid-phase and the analyte(s). As a consequence, harsher wash conditions can be tolerated during SPE methodology resulting in cleaner extracts. Because extraction selectivity is significantly improved, lower background is observed allowing analysts to achieve lower limits of detection.

Visit www.sigma-aldrich.com/supelmip to learn more.


Developed for the class-selective extraction of Amphetamine, Methamphetamine, Phentermine, MDA, MDMA, MDEA from human urine.

The method is highly reproducible and offers an average recovery greater than 80%; and limits of detection in the range of 0.8 - 12.9 pg/mL from 1 mL of urine.

Features and Benefits

• Highly selective SPE for trace analysis in complex matrices
• Achieve lower detection limits
• Significant time and cost savings
• Improved MS-compatibility

Legal Information

SupelMIP is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.


Certificate of Analysis (COA)

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Protocols & Articles


The Extraction of Amphetamine and Related Drugs using Molecularly Imprinted Polymer SPE

Amphetamine and amphetamine related drugs consist of a class of stimulants and hallucinogens used by students, athletes, and recreation drug users. Over the last 15 years, abuse of these drugs has be...
Christine Widstrand, Staffan Bergström, Anna-Karin Wihlborg1, An Trinh2
Reporter US Volume 26.1
Keywords: Clinical, Clinical Chemistry, Enzyme-linked immunosorbent assay, Forensic, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Solid phase extractions

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Keywords: Agriculture, Calorimetry, Environmental, Fractionation, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pesticides, Pharmaceutical, Solid phase extractions

Solid Phase Extraction: Fundamentals and Recent Developments [Webinar]

Solid Phase Extraction (SPE) has become a popular technique for sample preparation due to its convenience, effectiveness, relatively low solvent usage and versatility. The focus of this webinar is on...
Keywords: Sample preparations, Solid phase extractions

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