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PHL80380 Supelco

Catharanthine

phyproof® Reference Substance

Synonym: (+)-3,4-Didehydrocoronaridine, (2α,5β,6α,18β)-3,4-Didehydroibogamine-18-carboxylic acid methyl ester, 7-Ethyl-9,10,12,13-tetrahydro-6,9-methano-5H-pyrido[1′,2′:1,2]azepino[4,5-b]indole-6(6aH)-carboxylic acid methyl ester

  • CAS Number 2468-21-5

  • Empirical Formula (Hill Notation) C21H24N2O2

  • Molecular Weight 336.43

  •  MDL number MFCD01753356

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Properties

Related Categories A - D, Alkaloids / Nitrogen Containing Compounds, Alphabetical Index of Phytochemical Standards, Analytical Standards, Analytical/Chromatography,
InChI Key   CMKFQVZJOWHHDV-NQZBTDCJSA-N
product line   phyproof® Reference Substance
assay   ≥95.0% (HPLC)
Featured Industry   Food and Beverages

Description

General description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Catharanthine is a precursor of the anti-tumor drugs vinblastine and vincristine, formed by dimerization of catharanthine with vindoline. Catharanthine itself is an inhibitor of tubulin self-assembly into microtubules, although not so potent as vinblastine or vincristine. Catharanthine also has anticholinergic activity. It showed muscarinic antagonism at 10 microM and fully inhibited nicotinic receptor mediated diaphragm contractions with an IC50 of 59.6 microM.

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Safety Information

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Documents

Certificate of Analysis (COA)

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