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PHL80858

Nobiletin

phyproof® Reference Substance

Synonym: 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one, 3′,4′,5,6,7,8-Hexamethoxyflavone

  • CAS Number 478-01-3

  • Empirical Formula (Hill Notation) C21H22O8

  • Molecular Weight 402.39

  •  Beilstein/REAXYS Number 360887

  •  MDL number MFCD03273560

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Properties

Related Categories Alphabetical Index of Phytochemical Standards, Analytical Standards, Analytical/Chromatography, Flavonoids, N - R,
grade   primary reference standard
product line   phyproof® Reference Substance
assay   ≥98.0% (HPLC)
mfr. no.   PhytoLab
Featured Industry   Food and Beverages
SMILES string   COc1ccc(cc1OC)C2=CC(=O)c3c(OC)c(OC)c(OC)c(OC)c3O2
InChI   1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3
InChI key   MRIAQLRQZPPODS-UHFFFAOYSA-N

Description

General description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Nobiletin suppresses the expression of matrix metalloproteinases 1, 3 and 9, which participate in the break down of the extracellular matrix during tumor metastasis. Nobiletin is also involved in the increased expression of tissue inhibitor of matrix metalloproteinase 1 further preventing extracellular matrix degradation during tumor invasion. This bioflavonoid is believed to achieve both of these functions by disrupting the signal transduction pathway of Ras-Raf-MEK.

Legal Information

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis (COA)

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