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Y0002116

Propyl gallate for ID and assay

European Pharmacopoeia (EP) Reference Standard

Synonym: 3,4,5-Trihydroxybenzoic acid propyl ester, Propyl gallate

  • CAS Number 121-79-9

  • Linear Formula 3,4,5-(HO)3C6H2CO2CH2CH2CH3

  • Molecular Weight 212.20

  •  Beilstein/REAXYS Number 1877976

  •  MDL number MFCD00002196

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Properties

mfr. no.   EDQM
mp   146-149 °C (lit.)
storage temp.   2-8°C
SMILES string   CCCOC(=O)c1cc(O)c(O)c(O)c1
InChI   1S/C10H12O5/c1-2-3-15-10(14)6-4-7(11)9(13)8(12)5-6/h4-5,11-13H,2-3H2,1H3
InChI key   ZTHYODDOHIVTJV-UHFFFAOYSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein.

Biochem/physiol Actions

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis.

An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis.

Packaging

Unit quantity: 80 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Reconstitution

Prepare a 0.1M solution in glycerol:PBS (9:1)

Other Notes

Sales restrictions may apply.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
WGK Germany 
WGK 2
RTECS 
LW8400000
Flash Point(F) 
368.6 °F - closed cup
Flash Point(C) 
187 °C - closed cup

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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PHR1118 Propyl gallate, Pharmaceutical Secondary Standard; Certified Reference Material

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