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1029002 USP

Amitriptyline hydrochloride

United States Pharmacopeia (USP) Reference Standard

  • CAS Number 549-18-8

  • Empirical Formula (Hill Notation) C20H23N · HCl

  • Molecular Weight 313.86

  •  MDL number MFCD00012537

  •  PubChem Substance ID 329749005

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards A - B More...
grade   pharmaceutical primary standard
form   neat
mfr. no.   USP
Featured Industry   Pharmaceutical (small molecule)
format   neat
SMILES string   Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
InChI   1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
InChI key   KFYRPLNVJVHZGT-UHFFFAOYSA-N
Gene Information   human ... SLC6A2(6530), SLC6A4(6532)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with Kis of 100 nM and 14.7 nM, respectively; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.

Sales restrictions may apply.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

GC Analysis of Basic Drugs on Equity®-5

From our library of Articles, Sigma-Aldrich presents GC Analysis of Basic Drugs on Equity®-5
Keywords: Chromatography, Gas chromatography, Purification

HPLC Analysis of Tricyclic Antidepressants in Serum on Discovery® C18 after SPE using Discovery® DSC-18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Tricyclic Antidepressants in Serum on Discovery® C18 after SPE using Discovery® DSC-18
Keywords: Calorimetry, Chromatography, Clinical, High performance liquid chromatography, Pharmaceutical, Sample preparations, Solid phase extractions

HPLC Analysis of Tricyclic Antidepressants on Ascentis® C8

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Tricyclic Antidepressants on Ascentis® C8
Keywords: Anti-depressants, Chromatography, Clinical, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Tricyclic Antidepressants on Ascentis® ES Cyano

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Tricyclic Antidepressants on Ascentis® ES Cyano
Keywords: Anti-depressants, Chromatography, High performance liquid chromatography, Pharmaceutical, Separation

HPLC Analysis of Tricyclic Antidepressants on Ascentis® Express 2.7 μm RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Tricyclic Antidepressants on Ascentis® Express 2.7 μm RP-Amide
Keywords: Anti-depressants, Chromatography, High performance liquid chromatography, Pharmaceutical, Separation

UHPLC/MS/MS Analysis of 25 Small Molecule Pharmaceutical Compounds on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents UHPLC/MS/MS Analysis of 25 Small Molecule Pharmaceutical Compounds on Ascentis® Express RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Pharmaceutical, Separation

Peer-Reviewed Papers
15

References

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PHR1384 Amitriptyline hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

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