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1173508 USP

Desoximetasone

United States Pharmacopeia (USP) Reference Standard

Synonym: 9-Fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione

  • CAS Number 382-67-2

  • Empirical Formula (Hill Notation) C22H29FO4

  • Molecular Weight 376.46

  •  MDL number MFCD00083301

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards C - D More...
biological source   synthetic
Agency/Method   USP
vapor pressure   <0.0000001 kPa ( 25 °C)
form   powder
packaging   pkg of 200 mg
mfr. no.   USP
storage condition   protect from light
color   white
solubility   acetone: freely soluble
  alcohol: freely soluble
  benzene: slightly soluble
  chloroform: freely soluble
  ether: slightly soluble
  water: insoluble
Featured Industry   Pharmaceutical (small molecule)
SMILES string   [H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C
InChI   1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1
InChI key   VWVSBHGCDBMOOT-IIEHVVJPSA-N
Gene Information   human ... NR3C1(2908)

Description

General description

Desoximetasone is a topical corticosteroid known to modify the functions of leukocytes that are mainly responsible for skin infections, inflammation and allergies.

Application

Desoximetasone is used as an analytical standard for the determination of the analyte in pharmaceutical dosage forms by various analytical techniques.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.

Sales restrictions may apply.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Target organs 
Respiratory system
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Dexamethasone: An HPLC Assay and Impurity Profiling Following the USP

A simple, precise, and sensitive reversed-phase high performance liquid chromatography (RP-HPLC) gradient method was adapted for establishing traceability and total chromatographic analysis of dexame...
Keywords: Chromatography, High performance liquid chromatography, Reversed-phase chromatography, Separation

Peer-Reviewed Papers
15

References

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