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1176007 USP

Dexamethasone

United States Pharmacopeia (USP) Reference Standard

Synonym: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F

  • CAS Number 50-02-2

  • Empirical Formula (Hill Notation) C22H29FO5

  • Molecular Weight 392.46

  •  Beilstein/REAXYS Number 2066651

  •  MDL number MFCD00064136

  •  PubChem Substance ID 329749548

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards C - D More...
biological source   synthetic
grade   pharmaceutical primary standard
Agency/Method   USP
vapor pressure   <0.0000001 kPa ( 25 °C)
packaging   pkg of 125 mg
mfr. no.   USP
color   white
mp   262-264 °C (lit.)
solubility   acetone: sparingly soluble
  chloroform: slightly soluble
  ethanol: sparingly soluble
  ether: very slightly soluble
  methanol: sparingly soluble
  water: practically insoluble
Featured Industry   Pharmaceutical (small molecule)
storage temp.   2-8°C
SMILES string   C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
InChI   1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChI key   UREBDLICKHMUKA-CXSFZGCWSA-N
Gene Information   human ... NR3C1(2908)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dexamethasone USP reference standard may be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations, and biological samples by various analytical techniques.

Biochem/physiol Actions

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.

Sales restrictions may apply.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Dexamethasone: An HPLC Assay and Impurity Profiling Following the USP

A simple, precise, and sensitive reversed-phase high performance liquid chromatography (RP-HPLC) gradient method was adapted for establishing traceability and total chromatographic analysis of dexame...
Keywords: Chromatography, High performance liquid chromatography, Reversed-phase chromatography, Separation

Peer-Reviewed Papers
15

References

Related Products

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Description

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PHR1526 Dexamethasone, Pharmaceutical Secondary Standard; Certified Reference Material
08168 Timestrip Plus 8 °C

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