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1176506 USP

Dexamethasone acetate

United States Pharmacopeia (USP) Reference Standard

Synonym: 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate, 9α-Fluoro-16α-methylprednisolone-21-acetate, Dexamethasone 21-acetate, Prednisolone F acetate

  • CAS Number 1177-87-3

  • Empirical Formula (Hill Notation) C24H31FO6

  • Molecular Weight 434.50

  •  Beilstein/REAXYS Number 2342608

  •  MDL number MFCD00027407

  •  PubChem Substance ID 329749549

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards C - D More...
biological source   synthetic
grade   pharmaceutical primary standard
Agency/Method   USP
vapor pressure   <0.0000001 kPa ( 25 °C)
form   powder
packaging   pkg of 200 mg
mfr. no.   USP
color   white
mp   460.4-464 °F (238—240°C)
solubility   acetone: freely soluble
  dichloromethane: slightly soluble
  methanol: freely soluble
  water: practically insoluble
Featured Industry   Pharmaceutical (small molecule)
storage temp.   2-8°C
SMILES string   [H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COC(C)=O
InChI   1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,19+,21+,22+,23+,24+/m1/s1
InChI key   AKUJBENLRBOFTD-RPRRAYFGSA-N
Gene Information   human ... NR3C1(2908)

Description

General description

Dexamethasone acetate (Decadron-LA) belongs to the class of long-acting glucocorticoids, commonly used as a pharmaceutical ingredient in creams, ointments, microemulsions, lotions, aerosols, etc.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dexamethasone acetate is used as a pharmaceutical primary standard to quantify the analyte in pharmaceutical formulations using chromatography techniques.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.

Sales restrictions may apply.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Dexamethasone: An HPLC Assay and Impurity Profiling Following the USP

A simple, precise, and sensitive reversed-phase high performance liquid chromatography (RP-HPLC) gradient method was adapted for establishing traceability and total chromatographic analysis of dexame...
Keywords: Chromatography, High performance liquid chromatography, Reversed-phase chromatography, Separation

Peer-Reviewed Papers
15

References

Related Products

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08168 Timestrip Plus 8 °C
PHR1527 Dexamethasone Acetate, Pharmaceutical Secondary Standard; Certified Reference Material

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