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1250008 USP

Estradiol

United States Pharmacopeia (USP) Reference Standard

Synonym: β-Estradiol, 1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin

  • CAS Number 50-28-2

  • Empirical Formula (Hill Notation) C18H24O2

  • Molecular Weight 272.38

  •  Beilstein/REAXYS Number 1914275

  •  MDL number MFCD00003693

  •  PubChem Substance ID 329749749

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards E - F More...
grade   pharmaceutical primary standard
form   neat
mfr. no.   USP
mp   176-180 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
SMILES string   O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C
InChI   1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
InChI key   VOXZDWNPVJITMN-ZBRFXRBCSA-N
Gene Information   human ... ESR1(2099)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.

Sales restrictions may apply.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Estrogens on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Estrogens on Ascentis® Express Biphenyl
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Steroids on Ascentis® C18 (Mobile phase: 55:45)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Steroids on Ascentis® C18 (Mobile phase: 55:45)
Keywords: Chromatography, Clinical, High performance liquid chromatography

HPLC Analysis of Steroids on Ascentis® Express Biphenyl

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Steroids on Ascentis® Express Biphenyl
Keywords: Chromatography, High performance liquid chromatography

HPLC Analysis of Steroids on Ascentis® RP-Amide (Mobile phase: 55:45)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Steroids on Ascentis® RP-Amide (Mobile phase: 55:45)
Keywords: Chromatography, Clinical, High performance liquid chromatography

Hyper-Fast Separations on Ascentis® Express 2.7 μm at Half the Pressures of sub-2 μm Columns

From our library of Articles, Sigma-Aldrich presents Hyper-Fast Separations on Ascentis® Express 2.7 μm at Half the Pressures of sub-2 μm Columns
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

LC/MS/MS Analysis of Estradiol (Underivatized) from Patient Serum on Titan™ C18, 10 cm Column

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Estradiol (Underivatized) from Patient Serum on Titan™ C18, 10 cm Column
Keywords: Chromatography, Clinical, High performance liquid chromatography, Hormones, Liquid chromatography mass spectrometry, Mass spectrometry, Solvents

LC/MS/MS Analysis of Estradiol (Underivatized) from Patient Serum on Titan™ C18, 5 cm Column

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Estradiol (Underivatized) from Patient Serum on Titan™ C18, 5 cm Column
Keywords: Chromatography, Clinical, High performance liquid chromatography, Hormones, Liquid chromatography mass spectrometry, Mass spectrometry, Sample preparations, Solid phase extractions, Solvents

TLC Analysis of Hormones on HPTLC Silica Gel 60 RP-18 wF 254s with Concentrating Xone

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Hormones on HPTLC Silica Gel 60 RP-18 wF 254s with Concentrating Xone
Keywords: Chromatography, Thin layer chromatography

TLC Analysis of Hormones on HPTLC Silica Gel 60 RP-18 wF 254s with Concentrating Zone

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Hormones on HPTLC Silica Gel 60 RP-18 wF 254s with Concentrating Zone
Keywords: Chromatography, Thin layer chromatography

TLC Analysis of Hormones on HPTLC Silica Gel 60 RP-18 wF254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Hormones on HPTLC Silica Gel 60 RP-18 wF254s
Keywords: Thin layer chromatography

TLC Analysis of Ingredients in Dermatological Agents on HPTLC Silica Gel 60 RP-18 WF254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Ingredients in Dermatological Agents on HPTLC Silica Gel 60 RP-18 WF254s
Keywords: Pharmaceutical, Thin layer chromatography

UHPLC Analysis of Conjugated Estrogens on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Conjugated Estrogens on Ascentis® Express C18
Keywords: Chromatography, Clinical, Solvents

UHPLC Analysis of Conjugated Estrogens on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Conjugated Estrogens on Titan™ C18
Keywords: Chromatography, Clinical, Solvents

UHPLC/MS Analysis of Estradiols using Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents UHPLC/MS Analysis of Estradiols using Ascentis® Express C18
Keywords: Mass spectrometry

Peer-Reviewed Papers
15

References

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PHR1353 Estradiol, Pharmaceutical Secondary Standard; Certified Reference Material

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