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1327000 USP

Hydroxychloroquine sulfate

United States Pharmacopeia (USP) Reference Standard

Synonym: 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate, Hydroxychloroquine sulfate

  • CAS Number 747-36-4

  • Empirical Formula (Hill Notation) C18H26ClN3O · H2SO4

  • Molecular Weight 433.95

  •  EC Number 212-019-3

  •  MDL number MFCD00078203

  •  PubChem Substance ID 329750122

  •  NACRES NA.24

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Properties

Related Categories Analytical Standards, Analytical/Chromatography, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards G - H More...
biological source   synthetic
grade   pharmaceutical primary standard
Agency/Method   USP
form   neat
packaging   pkg of 200 mg
mfr. no.   USP
storage condition   protect from light
color   white to off-white
pH   3.5-5.5 (1% in aqueous solution, pH <6.0)
mp   388.4 °F (198°C; 240°C)
solubility   chloroform: practically insoluble
  ethanol: practically insoluble
  ether: practically insoluble
  water: soluble
Featured Industry   Pharmaceutical (small molecule)
format   neat
SMILES string   OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChI   1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
InChI key   JCBIVZZPXRZKTI-UHFFFAOYSA-N
Gene Information   human ... TLR7(51284), TLR9(54106)

Description

General description

Hydroxychloroquine Sulfate (Hydroxychloroquine Sulphate) is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydroxychloroquine Sulfate can be used as a pharmaceutical primary standard for the determination of the analyte in pharmaceutical formulations, and biological samples by various analytical techniques.

Biochem/physiol Actions

Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used in treating malaria.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.

Sales restrictions may apply.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Chloroquine Phosphate HPLC Assay and Impurity Profiling Methods Following the USP Monograph

A rapid, accurate, and simple method was implemented for the total chromatographic purity analysis of Chloroquine Phosphate by High Performance Liquid Chromatography with a Diode Array Detector. The ...
Keywords: Chromatography, High performance liquid chromatography, Separation

Peer-Reviewed Papers
15

References

Related Products

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PHR1782 Hydroxychloroquine Sulfate, Pharmaceutical Secondary Standard; Certified Reference Material

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