EMAIL THIS PAGE TO A FRIEND
1365000 USP

Levothyroxine

United States Pharmacopeia (USP) Reference Standard

Synonym: 3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, L-Thyroxine, T4

  • CAS Number 51-48-9

  • Linear Formula HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H

  • Molecular Weight 776.87

  •  Beilstein/REAXYS Number 2228515

  •  MDL number MFCD00002595

  •  PubChem Substance ID 329750052

  •  NACRES NA.24

Purchase

Properties

Related Categories Analytical Standards, Analytical/Chromatography, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards L - M More...
grade   pharmaceutical primary standard
form   neat
mfr. no.   USP
mp   223 °C (dec.) (lit.)
Featured Industry   Pharmaceutical (small molecule)
format   neat
SMILES string   N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
InChI   1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
InChI key   XUIIKFGFIJCVMT-LBPRGKRZSA-N
Gene Information   human ... THRA(7067), THRB(7068)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.

Sales restrictions may apply.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

HPLC Analysis of Thyroxine Enantiomers on Astec® CHIROBIOTIC® TAG

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Thyroxine Enantiomers on Astec® CHIROBIOTIC® TAG
Keywords: Chromatography, Clinical, Forensic, High performance liquid chromatography, Hormones, Mass spectrometry

LC/MS Analysis of Thyroid Hormones on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Thyroid Hormones on Ascentis® Express F5
Keywords: Chromatography, High performance liquid chromatography, Hormones, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Metabolites

LC/MS Analysis of thyroid hormones on Titan™ PFP

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of thyroid hormones on Titan™ PFP
Keywords: High performance liquid chromatography, Hormones, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Metabolites

LC/MS with Online Solid Phase Extraction (SPE-LC/MS) of Thyroid Hormones in Plasma on Ascentis® Express Phenyl-Hexyl using RP-Amide Traps

From our library of Articles, Sigma-Aldrich presents LC/MS with Online Solid Phase Extraction (SPE-LC/MS) of Thyroid Hormones in Plasma on Ascentis® Express Phenyl-Hexyl using RP-Amide Traps
Keywords: Chromatography, High performance liquid chromatography, Hormones, Liquid chromatography mass spectrometry, Mass spectrometry, Sample preparations, Separation, Solid phase extractions, Solvents

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?